TY - JOUR
T1 - Meta-analysis study of lymph node staging by 18 F-FDG PET/CT scan in non-small cell lung cancer
T2 - Comparison of TB and non-TB endemic regions
AU - Liao, Chih Ying
AU - Chen, Jin Hua
AU - Liang, Ji An
AU - Yeh, Jun Jun
AU - Kao, Chia Hung
N1 - Funding Information:
This study was supported by study–project grants (DMR-101-061 and DMR-101-080) from China Medical University Hospital and the Taiwan Department of Health Clinical Trial and Research Center for Excellence (DOH101-TD-B-111-004) and the Taiwan Department of Health Cancer Research Center for Excellence (DOH101-TD-C-111-005).
PY - 2012/11
Y1 - 2012/11
N2 - Lymph node staging in non-small cell lung cancer (NSCLC) is challenging and important for deciding treatment policy. The role of PET/CT scans in lymph node staging of NSCLC remains controversial when comparing TB and non-TB endemic regions. This study systematically reviews the literature regarding the diagnostic performance of PET/CT in lymph node staging of patients with NSCLC, and determines its pooled sensitivity and specicity. Methods: The databases of PubMed, Medline, and Cochrane library were searched for relevant studies. Two reviewers independently assessed the methodological quality of each study. A meta-analysis of the reported sensitivity and specicity of each study was performed. Results: Seven of 86 studies were included. These studies had moderate to good methodological quality. Pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio for patient-based analyses (five studies) were 66%, 92.7%, 5.86%, and 0.41%, respectively, and those for lesion-based analyses (six studies) were 59.4%, 96.5%, 9.37%, and 0.31%, respectively. Subanalysis of endemic regions of tuberculosis (TB) showed that these regions had lower sensitivity and similar specificity to non-TB endemic regions. Conclusion: PET/CT showed high specificity in the lymph node staging of NSCLC and lower sensitivity in TB endemic regions.
AB - Lymph node staging in non-small cell lung cancer (NSCLC) is challenging and important for deciding treatment policy. The role of PET/CT scans in lymph node staging of NSCLC remains controversial when comparing TB and non-TB endemic regions. This study systematically reviews the literature regarding the diagnostic performance of PET/CT in lymph node staging of patients with NSCLC, and determines its pooled sensitivity and specicity. Methods: The databases of PubMed, Medline, and Cochrane library were searched for relevant studies. Two reviewers independently assessed the methodological quality of each study. A meta-analysis of the reported sensitivity and specicity of each study was performed. Results: Seven of 86 studies were included. These studies had moderate to good methodological quality. Pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio for patient-based analyses (five studies) were 66%, 92.7%, 5.86%, and 0.41%, respectively, and those for lesion-based analyses (six studies) were 59.4%, 96.5%, 9.37%, and 0.31%, respectively. Subanalysis of endemic regions of tuberculosis (TB) showed that these regions had lower sensitivity and similar specificity to non-TB endemic regions. Conclusion: PET/CT showed high specificity in the lymph node staging of NSCLC and lower sensitivity in TB endemic regions.
KW - FDG PET/CT
KW - Lymph node staging
KW - Meta-analysis
KW - Non-small cell lung cancer
KW - TB
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U2 - 10.1016/j.ejrad.2012.02.007
DO - 10.1016/j.ejrad.2012.02.007
M3 - Review article
C2 - 22436434
AN - SCOPUS:84866993188
SN - 0720-048X
VL - 81
SP - 3518
EP - 3523
JO - European Journal of Radiology
JF - European Journal of Radiology
IS - 11
ER -
