(-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo

Hsu Fung Lu; Jia You Liu; Shu Ching Hsueh; Yi Yuan Yang; Jai Sing Yang; Tsu Wei Tan; Lai Fong Kok; Chi Cheng Lu; Sheng Huei Lan; Shan Ying Wu; Shiu Shin Liao; Siu Wan Ip; Jing Gung Chung

(-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo

Hsu Fung Lu
, Jia You Liu
, Shu Ching Hsueh
, Yi Yuan Yang
, Jai Sing Yang
, Tsu Wei Tan
, Lai Fong Kok
, Chi Cheng Lu
, Sheng Huei Lan
, Shan Ying Wu
, Shiu Shin Liao
, Siu Wan Ip
, Jing Gung Chung

研究成果: 雜誌貢獻 › 文章 › 同行評審

摘要

(-)-Menthol ([1-α]-5-methyl-2-[1-methylethyl]-cyclohexanol), is a widely used flavoring ingredient in mouthwash, foods, toothpaste and cigarettes. The studies reported here revealed that (-)-menthol induced cytotoxicity against murine leukemia WEHI-3 cells in vitro in a dose-dependent manner. The effects of (-)-menthol on WEHI-3 cells in vivo (BALB/c mice) were also examined, and it was observed that the Mac-3 and CD11b markers were decreased, indicating inhibition of differentiation of the precursor of macrophage and granulocyte. The weights of liver and spleen samples from mice treated with (-)-menthol were found to be decreased compared to untreated animals.

原文	英語
頁（從 - 到）	285-289
頁數	5
期刊	In Vivo
卷	21
發行號	2
出版狀態	已發佈 - 2007

UN SDG

此研究成果有助於以下永續發展目標

SDG 3 良好的健康和福祉

ASJC Scopus subject areas

一般生物化學，遺傳學和分子生物學
藥理
癌症研究

其它文件與鏈接

Link to publication in Scopus

引用此

@article{a9fcf01be74341bf89d8a0a9226407d2,

title = "(-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo",

abstract = "(-)-Menthol ([1-α]-5-methyl-2-[1-methylethyl]-cyclohexanol), is a widely used flavoring ingredient in mouthwash, foods, toothpaste and cigarettes. The studies reported here revealed that (-)-menthol induced cytotoxicity against murine leukemia WEHI-3 cells in vitro in a dose-dependent manner. The effects of (-)-menthol on WEHI-3 cells in vivo (BALB/c mice) were also examined, and it was observed that the Mac-3 and CD11b markers were decreased, indicating inhibition of differentiation of the precursor of macrophage and granulocyte. The weights of liver and spleen samples from mice treated with (-)-menthol were found to be decreased compared to untreated animals.",

keywords = "(-)-Menthol, Apoptosis, BALB/c mice, Cytotoxicity, WEHI-3 leukemia cells",

author = "Lu, \{Hsu Fung\} and Liu, \{Jia You\} and Hsueh, \{Shu Ching\} and Yang, \{Yi Yuan\} and Yang, \{Jai Sing\} and Tan, \{Tsu Wei\} and Kok, \{Lai Fong\} and Lu, \{Chi Cheng\} and Lan, \{Sheng Huei\} and Wu, \{Shan Ying\} and Liao, \{Shiu Shin\} and Ip, \{Siu Wan\} and Chung, \{Jing Gung\}",

year = "2007",

language = "English",

volume = "21",

pages = "285--289",

journal = "In Vivo",

issn = "0258-851X",

publisher = "International Institute of Anticancer Research",

number = "2",

}

TY - JOUR

T1 - (-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo

AU - Lu, Hsu Fung

AU - Liu, Jia You

AU - Hsueh, Shu Ching

AU - Yang, Yi Yuan

AU - Yang, Jai Sing

AU - Tan, Tsu Wei

AU - Kok, Lai Fong

AU - Lu, Chi Cheng

AU - Lan, Sheng Huei

AU - Wu, Shan Ying

AU - Liao, Shiu Shin

AU - Ip, Siu Wan

AU - Chung, Jing Gung

PY - 2007

Y1 - 2007

N2 - (-)-Menthol ([1-α]-5-methyl-2-[1-methylethyl]-cyclohexanol), is a widely used flavoring ingredient in mouthwash, foods, toothpaste and cigarettes. The studies reported here revealed that (-)-menthol induced cytotoxicity against murine leukemia WEHI-3 cells in vitro in a dose-dependent manner. The effects of (-)-menthol on WEHI-3 cells in vivo (BALB/c mice) were also examined, and it was observed that the Mac-3 and CD11b markers were decreased, indicating inhibition of differentiation of the precursor of macrophage and granulocyte. The weights of liver and spleen samples from mice treated with (-)-menthol were found to be decreased compared to untreated animals.

AB - (-)-Menthol ([1-α]-5-methyl-2-[1-methylethyl]-cyclohexanol), is a widely used flavoring ingredient in mouthwash, foods, toothpaste and cigarettes. The studies reported here revealed that (-)-menthol induced cytotoxicity against murine leukemia WEHI-3 cells in vitro in a dose-dependent manner. The effects of (-)-menthol on WEHI-3 cells in vivo (BALB/c mice) were also examined, and it was observed that the Mac-3 and CD11b markers were decreased, indicating inhibition of differentiation of the precursor of macrophage and granulocyte. The weights of liver and spleen samples from mice treated with (-)-menthol were found to be decreased compared to untreated animals.

KW - (-)-Menthol

KW - Apoptosis

KW - BALB/c mice

KW - Cytotoxicity

KW - WEHI-3 leukemia cells

UR - https://www.scopus.com/pages/publications/34047220360

UR - https://www.scopus.com/pages/publications/34047220360#tab=citedBy

M3 - Article

C2 - 17436578

AN - SCOPUS:34047220360

SN - 0258-851X

VL - 21

SP - 285

EP - 289

JO - In Vivo

JF - In Vivo

IS - 2

ER -

(-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo

摘要

UN SDG

ASJC Scopus subject areas

其它文件與鏈接

指紋

引用此