Melatonin prevents endotoxin-induced circulatory failure in rats

Chin Chen Wu, Chin Wei Chiao, George Hsiao, Ann Chen, Mao Hsiung Yen

研究成果: 雜誌貢獻文章同行評審

122 引文 斯高帕斯(Scopus)


The pineal secretory product melatonin was found to exert protective effects in septic shock. In a host infected by bacterial lipopolysaccharide (LPS), the expression and release of proinflammatory tumor necrosis factor-α (TNF-α) is rapidly increased, suggesting that TNF-α is associated with the etiology of endotoxic shock. Recent reports show that the expression of NO synthase (NOS) II and the production of superoxide anion (O2·-) also contribute to the pathophysiology of septic shock. In the present study we demonstrate that melatonin prevents circulatory failure in rats with endotoxemia and improves survival in mice treated with a lethal dose of LPS. The beneficial hemodynamic effects of melatonin in the endotoxemic animal appear to be associated with the inhibition of (i) the release of TNF-α in plasma, (ii) the expression of NOS II in liver, and (iii) the production of O2- in aortae. In addition, the infiltration of polymorphonuclear neutrophils into the liver from the surviving LPS mice treated with melatonin was reduced. Thus, our results support the clinical use of melatonin in endotoxemia.
頁(從 - 到)147-156
期刊Journal of Pineal Research
出版狀態已發佈 - 2001

ASJC Scopus subject areas

  • 內分泌


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