Mediating pathways from central obesity to childhood asthma: A population-based longitudinal study

An Hsuan Chih, Yang Ching Chen, Yu Kang Tu, Kuo Chin Huang, Tai Yuan Chiu, Yungling Leo Lee

研究成果: 雜誌貢獻文章同行評審

14 引文 斯高帕斯(Scopus)


The mediating pathways linking obesity and asthma are largely unknown. We aimed to investigate the mediating pathways and to search for the most prominent pathological mechanism between central obesity and childhood asthma. In the Taiwan Children Health Study, we collected data on an open cohort of children aged 9-13 years. Children's respiratory outcomes, atopic conditions, obesity measures and pulmonary function were surveyed annually between 2010 and 2012. Exhaled nitric oxide fraction concentrations were recorded in 2012. Generalised estimating equations and general linear models were used to examine the associations between central obesity, possible mediators and asthma. Structural equation models were applied to investigate the pathways that mediate the link between central obesity and asthma. Central obesity (waist-to-hip ratio) most accurately predicted childhood asthma. In the active asthma model, the percentage of mediation was 28.6% for pulmonary function, 18.1% for atopy and 5.7% for airway inflammation. The percentage of mediation for pulmonary function was 40.2% in the lifetime wheeze model. Pulmonary function was responsible for the greatest percentage of mediation among the three mediators in both models. Decline in pulmonary function is the most important pathway in central obesity related asthma. Pulmonary function screening should be applied to obese children for asthma risk prediction.

頁(從 - 到)748-757
期刊European Respiratory Journal
出版狀態已發佈 - 9月 1 2016

ASJC Scopus subject areas

  • 肺和呼吸系統醫學


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