Mechanism of vasorelaxation of thoracic aorta caused by xanthone

Yu W. Cheng, Jaw J. Kang

研究成果: 雜誌貢獻文章同行評審

30 引文 斯高帕斯(Scopus)


The effect of xanthone on smooth muscle was studied in thoracic aorta isolated from rats. Xanthone relaxed the norepinephrine-induced contraction of rat thoracic aorta. This relaxing effect of xanthone persisted in endothelium-denuded aorta suggesting that the relaxation induced by xanthone is endothelium-independent. The norepinephrine and high-K+-induced vasoconstriction was inhibited dose dependently in aorta pretreated with xanthone with IC50 values of 60.26 ± 8.43 and 82.9 ± 13.21 μM, respectively. The inositol 1,4,5-trisphosphate formation induced by norepinephrine (3 μM) in rat aorta was not affected by xanthone (10-100 μM), suggesting that the vasorelaxant effect of xanthone was not exerted on the receptor. Xanthone concentration dependently inhibited the 45Ca2+ influx induced by either norepinephrine or high-K+, suggesting that xanthone might act as a blocker of both receptor-operated and voltage-dependent Ca2+ channels. Furthermore, xanthone caused an increase in the level of intracellular cyclic adenosine 3',5'-monophosphate (cAMP), but not cyclic guanosine 3',5'-monophosphate (cGMP) content. These data suggested that the mechanism of xanthone-induced vasorelaxation might involve the increase of intracellular cyclic adenosine 3',5'-monophosphate (cAMP) content and block of Ca2+ channels.
頁(從 - 到)23-28
期刊European Journal of Pharmacology
出版狀態已發佈 - 10月 1 1997

ASJC Scopus subject areas

  • 細胞與分子神經科學
  • 藥理


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