Matrix Metalloproteinase-1 Polymorphism (-1607G) and Disease Severity in Non-Cystic Fibrosis Bronchiectasis in Taiwan

Meng Heng Hsieh; Pai Chien Chou; Chun Liang Chou; Shu Chuan Ho; Wen Ching Joa; Li Fei Chen; Te Fang Sheng; Horng Chyuan Lin; Tsai Yu Wang; Po Jui Chang; Chun Hua Wang; Han Pin Kuo

doi:10.1371/journal.pone.0066265

Matrix Metalloproteinase-1 Polymorphism (-1607G) and Disease Severity in Non-Cystic Fibrosis Bronchiectasis in Taiwan

Meng Heng Hsieh, Pai Chien Chou, Chun Liang Chou, Shu Chuan Ho, Wen Ching Joa, Li Fei Chen, Te Fang Sheng, Horng Chyuan Lin, Tsai Yu Wang, Po Jui Chang, Chun Hua Wang, Han Pin Kuo

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23 引文斯高帕斯（Scopus）

摘要

Objectives:Bronchiectasis is characterized by an irreversible dilatation of bronchi and is associated with lung fibrosis. MMP-1 polymorphism may alter its transcriptional activity, and differentially modulate bronchial destruction and lung fibrosis.Design:To investigate the association of MMP-1 polymorphisms with disease severity in non-cystic fibrosis (CF) bronchiectasis patients, 51 normal subjects and 113 patients with bronchiectasis were studied. The associations between MMP-1 polymorphisms, lung function, and disease severity evaluated by high resolution computed tomography (HRCT) were analyzed.Results:The frequency of MMP-1(-1607G) allele was significantly higher in patients with bronchiectasis than normal subjects (70.8% vs 45.1%, p

原文	英語
文章編號	e66265
期刊	PLoS ONE
卷	8
發行號	6
DOIs	https://doi.org/10.1371/journal.pone.0066265
出版狀態	已發佈 - 6月 11 2013
對外發佈	是

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多學科

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10.1371/journal.pone.0066265

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abstract = "Objectives:Bronchiectasis is characterized by an irreversible dilatation of bronchi and is associated with lung fibrosis. MMP-1 polymorphism may alter its transcriptional activity, and differentially modulate bronchial destruction and lung fibrosis.Design:To investigate the association of MMP-1 polymorphisms with disease severity in non-cystic fibrosis (CF) bronchiectasis patients, 51 normal subjects and 113 patients with bronchiectasis were studied. The associations between MMP-1 polymorphisms, lung function, and disease severity evaluated by high resolution computed tomography (HRCT) were analyzed.Results:The frequency of MMP-1(-1607G) allele was significantly higher in patients with bronchiectasis than normal subjects (70.8% vs 45.1%, p",

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AU - Hsieh, Meng Heng

AU - Chou, Pai Chien

AU - Chou, Chun Liang

AU - Ho, Shu Chuan

AU - Joa, Wen Ching

AU - Chen, Li Fei

AU - Sheng, Te Fang

AU - Lin, Horng Chyuan

AU - Wang, Tsai Yu

AU - Chang, Po Jui

AU - Wang, Chun Hua

AU - Kuo, Han Pin

PY - 2013/6/11

Y1 - 2013/6/11

N2 - Objectives:Bronchiectasis is characterized by an irreversible dilatation of bronchi and is associated with lung fibrosis. MMP-1 polymorphism may alter its transcriptional activity, and differentially modulate bronchial destruction and lung fibrosis.Design:To investigate the association of MMP-1 polymorphisms with disease severity in non-cystic fibrosis (CF) bronchiectasis patients, 51 normal subjects and 113 patients with bronchiectasis were studied. The associations between MMP-1 polymorphisms, lung function, and disease severity evaluated by high resolution computed tomography (HRCT) were analyzed.Results:The frequency of MMP-1(-1607G) allele was significantly higher in patients with bronchiectasis than normal subjects (70.8% vs 45.1%, p

AB - Objectives:Bronchiectasis is characterized by an irreversible dilatation of bronchi and is associated with lung fibrosis. MMP-1 polymorphism may alter its transcriptional activity, and differentially modulate bronchial destruction and lung fibrosis.Design:To investigate the association of MMP-1 polymorphisms with disease severity in non-cystic fibrosis (CF) bronchiectasis patients, 51 normal subjects and 113 patients with bronchiectasis were studied. The associations between MMP-1 polymorphisms, lung function, and disease severity evaluated by high resolution computed tomography (HRCT) were analyzed.Results:The frequency of MMP-1(-1607G) allele was significantly higher in patients with bronchiectasis than normal subjects (70.8% vs 45.1%, p

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Matrix Metalloproteinase-1 Polymorphism (-1607G) and Disease Severity in Non-Cystic Fibrosis Bronchiectasis in Taiwan

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