Manganese-enhanced MRI of rat brain based on slow cerebral delivery of manganese(II) with silica-encapsulated MnxFe1-xO nanoparticles

Wei Chen, Fang Lu, Chiao Chi V. Chen, Kuan Chi Mo, Yann Hung, Zhi Xuan Guo, Chia Hui Lin, Ming Huang Lin, Yu Hsuan Lin, Chen Chang, Chung Yuan Mou

研究成果: 雜誌貢獻文章同行評審

21 引文 斯高帕斯(Scopus)


In this work, we report a monodisperse bifunctional nanoparticle system, MIO@SiO2-RITC, as an MRI contrast agent [core, manganese iron oxide (MIO); shell, amorphous silica conjugated with rhodamine B isothiocyanate (RITC)]. It was prepared by thermal decomposition and modified microemulsion methods. The nanoparticles with varying iron to manganese ratios displayed different saturated magnetizations and relaxivities. In vivo MRI of rats injected intravenously with MIO@SiO2-RITC nanoparticles exhibited enhancement of the T1 contrast in brain tissue, in particular a time-delayed enhancement in the hippocampus, pituitary gland, striatum and cerebellum. This is attributable to the gradual degradation of MIO@SiO2-RITC nanoparticles in the liver, resulting in the slow release of manganese(II) [Mn(II)] into the blood pool and, subsequently, accumulation in the brain tissue. Thus, T1-weighted contrast enhancement was clearly detected in the anatomic structure of the brain as time progressed. In addition, T2z.ast;-weighted images of the liver showed a gradual darkening effect. Here, we demonstrate the concept of the slow release of Mn(II) for neuroimaging. This new nanoparticle-based manganese contrast agent allows one simple intravenous injection (rather than multiple infusions) of Mn(II) precursor, and results in delineation of the detailed anatomic neuroarchitecture in MRI; hence, this provides the advantage of the long-term study of neural function.

頁(從 - 到)1176-1185
期刊NMR in Biomedicine
出版狀態已發佈 - 9月 2013

ASJC Scopus subject areas

  • 分子醫學
  • 放射學、核子醫學和影像學
  • 光譜


深入研究「Manganese-enhanced MRI of rat brain based on slow cerebral delivery of manganese(II) with silica-encapsulated MnxFe1-xO nanoparticles」主題。共同形成了獨特的指紋。