TY - JOUR
T1 - Mammalian target of rapamycin and head and neck squamous cell carcinoma
AU - Liao, Yu Min
AU - Kim, Charles
AU - Yen, Yun
PY - 2011/4/26
Y1 - 2011/4/26
N2 - Head and neck squamous cell carcinoma (HNSCC), a significant cause of cancer deaths worldwide, has multiple stepwise malignant evolutions. Mammalian target of rapamycin (mTOR) plays a critical role in tumor development, invasion, metastasis and angiogenesis that impact local recurrence and survival. mTOR can also act as a biomarker for personalized adjuvant therapy. In in vivo and in vitro studies, mTOR inhibitor suppresses tumor growth and sensitizes HNSCC to radiation, cytotoxic agents and epidermoid growth factor receptor inhibitors. We have reviewed the pathogenesis of HNSCC, mTOR pathway, mTOR inhibitor and the role of mTOR in HNSCC.
AB - Head and neck squamous cell carcinoma (HNSCC), a significant cause of cancer deaths worldwide, has multiple stepwise malignant evolutions. Mammalian target of rapamycin (mTOR) plays a critical role in tumor development, invasion, metastasis and angiogenesis that impact local recurrence and survival. mTOR can also act as a biomarker for personalized adjuvant therapy. In in vivo and in vitro studies, mTOR inhibitor suppresses tumor growth and sensitizes HNSCC to radiation, cytotoxic agents and epidermoid growth factor receptor inhibitors. We have reviewed the pathogenesis of HNSCC, mTOR pathway, mTOR inhibitor and the role of mTOR in HNSCC.
UR - http://www.scopus.com/inward/record.url?scp=79955025748&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955025748&partnerID=8YFLogxK
U2 - 10.1186/1758-3284-3-22
DO - 10.1186/1758-3284-3-22
M3 - Review article
C2 - 21513566
AN - SCOPUS:79955025748
SN - 1758-3284
VL - 3
JO - Head and Neck Oncology
JF - Head and Neck Oncology
IS - 1
M1 - 22
ER -
