Malignant Otitis Externa is Associated with Diabetes: A Population-Based Case-Control Study

Tzong Hann Yang, Sudha Xirasagar, Yen Fu Cheng, Chuan Song Wu, Yi Wei Kao, Ben Chang Shia, Herng Ching Lin

研究成果: 雜誌貢獻文章同行評審

19 引文 斯高帕斯(Scopus)


Objective: Despite studies reporting a possible association between malignant otitis externa (MOE) and diabetes, there are no large-scale population-based empirical studies. This nationwide, population-based case-control study explored the association of MOE occurrence with previously diagnosed diabetes. Methods: Data were retrieved from Taiwan’s National Health Insurance Research Database, 753 patients with MOE (cases) and 2 259 propensity score-matched patients without MOE (controls). Multiple logistic regressions were conducted to examine the association of MOE with previously diagnosed diabetes. Results: In total, 728 (24.2%) out of 3 012 sample patients had diabetes prior to the index date. Chi-square test revealed a significant difference in diabetes prevalence among cases and controls (54.8% vs 13.9%, p < 0.001). Simple logistic regression showed the odds ratio for prior diabetes among cases versus controls was 7.50 (95% CI, 6.22~9.03). The adjusted odds ratio of prior diabetes for cases versus controls was 10.07 (95% CI, 8.15~12.44) after adjusting for patient demographics and medical co-morbidities. Conclusions: This study found an association between MOE and diabetes. One clinical practice implication of our study is that when a patient with diabetes complains of otalgia or otorrhea, and physical examination shows swelling of the ear canal or granulation growth, physicians should consider the possibility of MOE.

頁(從 - 到)585-590
期刊Annals of Otology, Rhinology and Laryngology
出版狀態已發佈 - 6月 1 2020

ASJC Scopus subject areas

  • 耳鼻咽喉科


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