Magneto-Phototherapeutic Nanocarriers with Bio-Intellectual Plasma-Fabricated Platelet Lysates to Alleviate Inflammation

The prevalence of inflammatory diseases demands precise and effective treatments. Nanoparticle-based drug delivery systems offer significant promise for targeted therapy, enhancing drug delivery while minimizing off-target effects. In this study, we investigated the efficacy of platelet lysates and iron oxide nanocarriers loaded with diferuloylmethane (PLT-NC-DIF NCs) in treating skin and brain inflammation. Using mouse models with lipopolysaccharide (LPS)-induced inflammation, we assessed the potential of PLT-NC-DIF NCs through in vivo imaging, thermal evaluation, histological inspection, and spectroscopic analyses. Our findings showed that PLT-NC-DIF NCs effectively targeted inflammatory lesions, significantly reducing inflammatory markers and oxidative stress. The combination of an external magnetic field and near-infrared (NIR) irradiation further amplified therapeutic outcomes. The nanocomposite demonstrated acceptable biosafety, highlighting their potential for clinical translation. This study underscores the promise of PLT-NC-DIF NCs as a targeted therapy for inflammation, offering customized treatment options that minimize side effects and improve therapeutic results. Additional clinical validation is needed to fully realize the potential of PLT-NC-DIF NCs in treating inflammatory disorders.