Lymphoepithelioma-like cholangiocarcinoma: An Epstein-Barr virus-associated tumor

Yung Ming Jeng, Chi Long Chen, Hey C. Hsu

研究成果: 雜誌貢獻文章同行評審

78 引文 斯高帕斯(Scopus)


Epstein-Barr virus (EBV) has been linked to carcinomas of several body sites, especially of the nasopharynx, salivary gland, lung, and stomach. We present five cases of lymphoepithelioma-like cholangiocarcinoma, including one that had been previously reported. Two patients were men and three were women. Their ages ranged from 42 to 66 years. Histologically, all five tumors were composed of variable proportions of undifferentiated epithelial cells and glandular components in a lymphocyte-rich stroma. EBV was detected in all five tumors by in situ hybridization for EBER-1 in both lymphoepithelioma-like carcinoma (LELC) and glandular parts, but not in 36 cases of cholangiocarcinoma without the LELC component. Taken together, these observations indicate that lymphoepithelioma-like cholangiocarcinoma is strongly linked to EBV. The LELC type of cholangiocarcinoma, like LELC of other body sites, may be more common in areas with endemic EBV infection.

頁(從 - 到)516-520
期刊American Journal of Surgical Pathology
出版狀態已發佈 - 2001

ASJC Scopus subject areas

  • 解剖學
  • 病理學與法醫學


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