Luteinizing hormone-releasing hormone neurons express c-fos antigen after steroid activation

G. E. Hoffman, W. S. Lee, B. Attardi, V. Yann, M. D. Fitzsimmons

研究成果: 雜誌貢獻文章同行評審

196 引文 斯高帕斯(Scopus)


Immature female rats received implants containing 17β-estradiol on postnatal day 28 at 0900 h, followed 24 h later by either blank capsules or progesterone. Between 15001600 h on the day of progesterone (or blank capsule) implantation, these rats, a group of unoperated or sham controls, and a group of estrogen-progesterone-treated immature male rats were killed and perfused, and their brains processed for immunocy-tochemistry of c-fos antigen and LHRH. LHRH neurons consistently expressed c-fos after estrogen-progesterone treatment in females but not males; in only one of four females examined was c-fos induced after estrogen treatment. No fos was associated with LHRH neurons in the control groups. The LHRH neurons that expressed c-fos were located in the preoptic area and ante-rior hypothalamus; more rostral LHRH cells did not appear stimulated. These data demonstrate that gonadal steroids, administered in a paradigm that predictably produces timed stimulation of LH release, induce c-/os in LHRH neurons. The induction of c-fos in LHRH neurons provides a potentially useful and powerful tool for studying LHRH activation at the cellular level.

頁(從 - 到)1736-1741
出版狀態已發佈 - 3月 1990

ASJC Scopus subject areas

  • 內分泌


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