Lung cancer model on chip for drug testing

Kuo Wei Chang; Tushar Harishchandra Punde; Gaurav Prashant Pendharkar; Po Chen Shih; Yao Fei Chan; Kang Yun Lee; Ming Yan Chen; Cheng Hsien Liu

doi:10.1109/TRANSDUCERS.2015.7181006

Lung cancer model on chip for drug testing

Kuo Wei Chang, Tushar Harishchandra Punde, Gaurav Prashant Pendharkar, Po Chen Shih, Yao Fei Chan, Kang Yun Lee, Ming Yan Chen, Cheng Hsien Liu

研究成果: 書貢獻/報告類型 › 會議貢獻

摘要

In this paper we have simulated an in vitro lung cancer microenvironment by dielectrophoresis (DEP) patterning. Heterogeneous cells were patterned on the glass substrate, above which a microfluidic gradient is integrated to generate different concentration of target therapy drug (Iressa). Taking advantage of DEP pattern and microfluidic gradient, we designed a biochip to mimic the in vivo conditions. The influence of drug treatment for cell patterning is better than the non-patterned case as visualized in cell viability rate by MTT assay.

原文	英語
主出版物標題	2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
發行者	Institute of Electrical and Electronics Engineers Inc.
頁面	646-649
頁數	4
ISBN（列印）	9781479989553
DOIs	https://doi.org/10.1109/TRANSDUCERS.2015.7181006
出版狀態	已發佈 - 8月 5 2015
事件	18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 - Anchorage, 美国持續時間: 6月 21 2015 → 6月 25 2015

其他

其他	18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015
國家/地區	美国
城市	Anchorage
期間	6/21/15 → 6/25/15

ASJC Scopus subject areas

儀器
電氣與電子工程

UN SDG

此研究成果有助於以下永續發展目標

存取文件

10.1109/TRANSDUCERS.2015.7181006

其它文件與鏈接

引用此

Chang, K. W., Punde, T. H., Pendharkar, G. P., Shih, P. C., Chan, Y. F., Lee, K. Y., Chen, M. Y., & Liu, C. H. (2015). Lung cancer model on chip for drug testing. 於 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 (頁 646-649). 文章 7181006 Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/TRANSDUCERS.2015.7181006

Lung cancer model on chip for drug testing. / Chang, Kuo Wei; Punde, Tushar Harishchandra; Pendharkar, Gaurav Prashant 等.
2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015. Institute of Electrical and Electronics Engineers Inc., 2015. p. 646-649 7181006.

研究成果: 書貢獻/報告類型 › 會議貢獻

Chang, KW, Punde, TH, Pendharkar, GP, Shih, PC, Chan, YF, Lee, KY, Chen, MY & Liu, CH 2015, Lung cancer model on chip for drug testing. 於 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015., 7181006, Institute of Electrical and Electronics Engineers Inc., 頁 646-649, 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015, Anchorage, 美国, 6/21/15. https://doi.org/10.1109/TRANSDUCERS.2015.7181006

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title = "Lung cancer model on chip for drug testing",

abstract = "In this paper we have simulated an in vitro lung cancer microenvironment by dielectrophoresis (DEP) patterning. Heterogeneous cells were patterned on the glass substrate, above which a microfluidic gradient is integrated to generate different concentration of target therapy drug (Iressa). Taking advantage of DEP pattern and microfluidic gradient, we designed a biochip to mimic the in vivo conditions. The influence of drug treatment for cell patterning is better than the non-patterned case as visualized in cell viability rate by MTT assay.",

keywords = "Dielectrophoresis, Gradient Microchannel, Lung Cancer Patterned, Target Therapy Drug",

author = "Chang, {Kuo Wei} and Punde, {Tushar Harishchandra} and Pendharkar, {Gaurav Prashant} and Shih, {Po Chen} and Chan, {Yao Fei} and Lee, {Kang Yun} and Chen, {Ming Yan} and Liu, {Cheng Hsien}",

year = "2015",

month = aug,

day = "5",

doi = "10.1109/TRANSDUCERS.2015.7181006",

language = "English",

isbn = "9781479989553",

pages = "646--649",

booktitle = "2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015",

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note = "18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015 ; Conference date: 21-06-2015 Through 25-06-2015",

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AU - Chang, Kuo Wei

AU - Punde, Tushar Harishchandra

AU - Pendharkar, Gaurav Prashant

AU - Shih, Po Chen

AU - Chan, Yao Fei

AU - Lee, Kang Yun

AU - Chen, Ming Yan

AU - Liu, Cheng Hsien

PY - 2015/8/5

Y1 - 2015/8/5

N2 - In this paper we have simulated an in vitro lung cancer microenvironment by dielectrophoresis (DEP) patterning. Heterogeneous cells were patterned on the glass substrate, above which a microfluidic gradient is integrated to generate different concentration of target therapy drug (Iressa). Taking advantage of DEP pattern and microfluidic gradient, we designed a biochip to mimic the in vivo conditions. The influence of drug treatment for cell patterning is better than the non-patterned case as visualized in cell viability rate by MTT assay.

AB - In this paper we have simulated an in vitro lung cancer microenvironment by dielectrophoresis (DEP) patterning. Heterogeneous cells were patterned on the glass substrate, above which a microfluidic gradient is integrated to generate different concentration of target therapy drug (Iressa). Taking advantage of DEP pattern and microfluidic gradient, we designed a biochip to mimic the in vivo conditions. The influence of drug treatment for cell patterning is better than the non-patterned case as visualized in cell viability rate by MTT assay.

KW - Dielectrophoresis

KW - Gradient Microchannel

KW - Lung Cancer Patterned

KW - Target Therapy Drug

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UR - http://www.scopus.com/inward/citedby.url?scp=84955489408&partnerID=8YFLogxK

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DO - 10.1109/TRANSDUCERS.2015.7181006

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EP - 649

BT - 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 18th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2015

Y2 - 21 June 2015 through 25 June 2015

ER -

Lung cancer model on chip for drug testing

摘要

其他

ASJC Scopus subject areas

UN SDG

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