TY - JOUR
T1 - Lower urinary tract infection and subsequent risk of prostate cancer
T2 - A nationwide population-based cohort study
AU - Fan, Chao Yueh
AU - Huang, Wen Yen
AU - Lin, Kuen Tze
AU - Lin, Chun Shu
AU - Chao, Hsing Lung
AU - Yang, Jen Fu
AU - Lin, Cheng Li
AU - Kao, Chia Hung
N1 - Publisher Copyright:
© 2017 Fan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2017/1
Y1 - 2017/1
N2 - Purpose We investigated whether lower urinary tract infection (LUTI), including cystitis or urethritis, is associated with an increased risk of developing prostate cancer (PCA), in a nationwide population-based cohort study. Methods We identified 14,273 men newly diagnosed with LUTI (9347 with cystitis, and 4926 with urethritis) between 1998 and 2011, from the Taiwan Longitudinal Health Insurance Database 2000. Each patient was randomly frequency-matched with 4 men without LUTI, based on age and index year of diagnosis. Cox's proportional hazard regression analysis was performed to estimate the effect of LUTI on the PCA risk. Results The risk of developing PCA was significantly higher in the cystitis cohort (adjusted HR = 1.46, 95% CI = 1.20±1.78) and in the urethritis cohort (adjusted HR = 1.72, 95% CI = 1.26 ± 2.34) than in the group without LUTI. Further analyses indicated that patients with more than 5 medical visits for LUTI per year had a significantly greater risk of developing PCA. Conclusion We found that cystitis or urethritis may play an etiological role in the development of PCA in Taiwanese men, particularly in those with repeated medical visits for cystitis or urethritis. Further studies are warranted on the association between LUTI and PCA in other countries, particularly where the prevalence of PCA is high.
AB - Purpose We investigated whether lower urinary tract infection (LUTI), including cystitis or urethritis, is associated with an increased risk of developing prostate cancer (PCA), in a nationwide population-based cohort study. Methods We identified 14,273 men newly diagnosed with LUTI (9347 with cystitis, and 4926 with urethritis) between 1998 and 2011, from the Taiwan Longitudinal Health Insurance Database 2000. Each patient was randomly frequency-matched with 4 men without LUTI, based on age and index year of diagnosis. Cox's proportional hazard regression analysis was performed to estimate the effect of LUTI on the PCA risk. Results The risk of developing PCA was significantly higher in the cystitis cohort (adjusted HR = 1.46, 95% CI = 1.20±1.78) and in the urethritis cohort (adjusted HR = 1.72, 95% CI = 1.26 ± 2.34) than in the group without LUTI. Further analyses indicated that patients with more than 5 medical visits for LUTI per year had a significantly greater risk of developing PCA. Conclusion We found that cystitis or urethritis may play an etiological role in the development of PCA in Taiwanese men, particularly in those with repeated medical visits for cystitis or urethritis. Further studies are warranted on the association between LUTI and PCA in other countries, particularly where the prevalence of PCA is high.
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U2 - 10.1371/journal.pone.0168254
DO - 10.1371/journal.pone.0168254
M3 - Article
C2 - 28046120
AN - SCOPUS:85008318904
SN - 1932-6203
VL - 12
JO - PLoS ONE
JF - PLoS ONE
IS - 1
M1 - e0168254
ER -