@article{f45156aa02d2477da5df4d5e97f6446b,
title = "Longitudinal changes in physical and mental health of older adults with chronic hepatitis B infection: Trajectories and predictors",
abstract = "Despite the increasing health burden of chronic hepatitis B (CHB) in aging populations, little is known about the course of health-related quality of life (HRQoL) changes. We aimed to assess individual-level longitudinal HRQoL changes in elderly patients with CHB and to examine their correlates. A prospective 5.1 years-cohort study was conducted in community-dwelling adults aged 55 years with hepatitis B surface antigen-positive. Participants underwent serial measurement of HRQoL using the short-form (12) health survey version 2. Of 503 participants, 82.7% remained in good physical health throughout the study period, whereas 9.1% had declining physical health and 8.2% were in poor physical health. We likewise identified three trajectories of mental health changes (“good mental health” [86.9%], “declining mental health” [6.8%], and “poor mental health” [6.4%]). Three baseline characteristics were independently associated with a lower likelihood of remaining physically or mentally healthy: sarcopenic obesity (odds ratio [OR] with 95% confidence interval [95% CI] of 7.5 [2.8–20.5] for poor physical health, 3.1 [1.1–8.4] for declining physical health, 4.3 [1.4–13.0] for poor mental health), a higher number of metabolic abnormalities (OR [95% CI] of 3.6 [1.6–8.0] for poor physical health) and depressed mood (OR [95% CI] of 21.7 [5.8–81.0] for poor physical health, 5.3 [1.4–19.9] for declining physical health, 83.1 [19.7–350.2] for poor mental health, 13.6 [2.9–64.8] for declining mental health). In conclusion, in a cohort of elderly patients with CHB, we demonstrated the heterogeneity and nonlinearity of HRQoL changes and their associations with variations in specific extrahepatic organs/systems.",
keywords = "Aging, Geriatric assessment, Group-based trajectory modeling, Health-related quality of life, Healthy Aging Longitudinal Study in Taiwan (HALST)",
author = "Chen, {Chang Hua} and Wu, {Ming Shiang} and Yang, {Yu Wen} and Liu, {Yen Tze} and Chiu, {Yen Feng} and Hsu, {Chih Cheng} and Chuang, {Shu Chun} and Chung, {Tieh Chi} and Tsai, {Tsung Lung} and Huang, {Wen Hao} and Huang, {Wei Lin} and Juan, {Chung Chou} and Lien, {Li Ming} and Hsiung, {Chao A.} and Wu, {I. Chien}",
note = "Funding Information: We wish to thank all members of the HALST study group. The members of the HALST study group are as follows: Drs. Chao-Agnes Hsiung, Chih-Cheng Hsu, I-Chien Wu, Hsing-Yi Chang, Chu-Chih Chen, Yen-Feng Chiu, Hui-Ju Tsai, and Shu-Chun Chuang of the National Heath Research Institutes; Dr. Ching-Yu Chen of National Taiwan University; Dr. Kiang Liu of Northwestern University Medical School; Dr. Marion Lee of University of California at San Francisco; Dr. Ida Chen of University of California at Los Angeles; Dr. Li-Ming Lien of Shin Kong Wu Ho-su Memorial Hospital; Dr. Wen-Jin Liaw of Yee Zen General Hospital; Dr. Tieh-Chi Chung of Hope Doctors Hospital; Dr. I-Ching Lin of Changhua Christian Hospital; Dr. Tsung-Lung Tsai of Puzi Hospital; Dr. Chung-Chou Juan of Yuan's General Hospital; and Dr. Chi-Chung Wang of Mennonite Christian Hospital. We also acknowledge the significant contributions of the HALST staff. Funding Information: This work was supported by the National Health Research Institutes in Taiwan. (Project nos. BS-097-SP-04, PH-098-SP-02, PH-099-SP-01, PH-100-SP-01, PH-101-SP-01, PH-102-SP-01, PH-103-SP-01, PH-104-SP-01, PH-105-SP-01, PH-106-SP-01, PH-107-SP-01, PH-107-PP-22, PH-108-SP-01, PH-108-PP-22). The sponsors had no roles in the design, methods, subject recruitment, data collections, analysis, or preparation of the paper. Publisher Copyright: {\textcopyright} 2021 The Author(s)",
year = "2021",
month = sep,
doi = "10.1016/j.pmedr.2021.101432",
language = "English",
volume = "23",
journal = "Preventive Medicine Reports",
issn = "2211-3355",
publisher = "Elsevier Inc.",
}