Longitudinal changes in physical and mental health of older adults with chronic hepatitis B infection: Trajectories and predictors

Chang Hua Chen, Ming Shiang Wu, Yu Wen Yang, Yen Tze Liu, Yen Feng Chiu, Chih Cheng Hsu, Shu Chun Chuang, Tieh Chi Chung, Tsung Lung Tsai, Wen Hao Huang, Wei Lin Huang, Chung Chou Juan, Li Ming Lien, Chao A. Hsiung, I. Chien Wu

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)


Despite the increasing health burden of chronic hepatitis B (CHB) in aging populations, little is known about the course of health-related quality of life (HRQoL) changes. We aimed to assess individual-level longitudinal HRQoL changes in elderly patients with CHB and to examine their correlates. A prospective 5.1 years-cohort study was conducted in community-dwelling adults aged 55 years with hepatitis B surface antigen-positive. Participants underwent serial measurement of HRQoL using the short-form (12) health survey version 2. Of 503 participants, 82.7% remained in good physical health throughout the study period, whereas 9.1% had declining physical health and 8.2% were in poor physical health. We likewise identified three trajectories of mental health changes (“good mental health” [86.9%], “declining mental health” [6.8%], and “poor mental health” [6.4%]). Three baseline characteristics were independently associated with a lower likelihood of remaining physically or mentally healthy: sarcopenic obesity (odds ratio [OR] with 95% confidence interval [95% CI] of 7.5 [2.8–20.5] for poor physical health, 3.1 [1.1–8.4] for declining physical health, 4.3 [1.4–13.0] for poor mental health), a higher number of metabolic abnormalities (OR [95% CI] of 3.6 [1.6–8.0] for poor physical health) and depressed mood (OR [95% CI] of 21.7 [5.8–81.0] for poor physical health, 5.3 [1.4–19.9] for declining physical health, 83.1 [19.7–350.2] for poor mental health, 13.6 [2.9–64.8] for declining mental health). In conclusion, in a cohort of elderly patients with CHB, we demonstrated the heterogeneity and nonlinearity of HRQoL changes and their associations with variations in specific extrahepatic organs/systems.
期刊Preventive Medicine Reports
出版狀態已發佈 - 9月 2021

ASJC Scopus subject areas

  • 健康資訊學
  • 公共衛生、環境和職業健康


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