Long-term impacts of endocrine-disrupting chemicals exposure on kidney function: A community-based cohort study

Chun Yu Chen, Chin Chan Lee, Heng Jung Hsu, I. Wen Wu, Yung Chang Chen, Heng Chih Pan, Yih Ting Chen, Cheng Kai Hsu, Chiao Yin Sun

研究成果: 雜誌貢獻文章同行評審

摘要

This study explores the extended renal effects of endocrine-disrupting chemicals (EDCs) exposure, a linkage already established with adverse health outcomes, notably chronic kidney disease. To delve deeper, the Chang Gung Community Research Center conducted a longitudinal study with 887 participants. Among them, 120 individuals were scrutinized based on EDC scores, analyzing 17 urinary EDCs and renal function. Findings revealed elevated mono-(2-ethylhexyl) phthalate (MEHP) and bisphenol A levels in higher EDC exposure cases. MEHP notably correlated with increased urinary albumin-to-creatinine ratio (UACR), predicting a > 15% decline in estimated glomerular filtration rate. Higher MEHP levels also hinted at declining renal function. UACR escalation linked significantly with specific EDCs: MEHP, methylparaben, nonylphenol, and 4-tert-octylphenol. This research underscores enduring renal hazards tied to environmental EDC exposure, particularly MEHP, emphasizing the urgent call for robust preventive public health strategies.
原文英語
文章編號104379
期刊Environmental Toxicology and Pharmacology
106
DOIs
出版狀態已發佈 - 3月 2024

ASJC Scopus subject areas

  • 毒理學
  • 藥理
  • 健康、毒理學和誘變

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