LOCATION OF DISULFIDE BRIDGES IN CARDIOTOXIN FROM THE VENOM OF FORMOSAN COBRA (NAJA NAJA ATRA)

The location of the four disulfide bridges in cardiotoxin from the venom of the Formosan cobra, Naja naja atra, was determined by isolating cystine‐containing peptides from the enzymic and partial acid hydrolyzates of the intact toxin. The results indicate that the disulfide bridges are formed by half cystine residues 3–21, 14–38, 42–53, and 54–59. The amino acid sequence at the position 48–49 was revised to ‐Leu‐Val‐ instead of ‐Val‐Leu‐ as reported previously.