TY - JOUR
T1 - Liposome-encapsulated photosensitizers against bacteria
AU - Chen, Chin Tin
AU - Chen, Chueh Pin
AU - Yang, Jen Chang
AU - Tsai, Tsuimin
PY - 2013
Y1 - 2013
N2 - Photodynamic therapy (PDT), utilizing photosensitizers and light, has received considerable interests for its potential to treat microbial infections. The advantages of antimicrobial PDT include a broad spectrum of action, efficient killing against wild-type as well as drug-resistant pathogens. Therefore, antimicrobial PDT could be valuable to rapidly reduce the microbial burden during the management of local infections, especially for the antibiotic resistance. A variety of photosensitizers have been examined its efficacy against pathogens. To increase the efficacy of photosensitizers, various drug delivery systems have been developed. Among these carrier systems, liposomes showed their PDT efficacy and safety in delivering photosensitizers. This review is focused on the application of liposomes mediated photodynamic inactivation of bacteria along with the discussion of few of recent patents.
AB - Photodynamic therapy (PDT), utilizing photosensitizers and light, has received considerable interests for its potential to treat microbial infections. The advantages of antimicrobial PDT include a broad spectrum of action, efficient killing against wild-type as well as drug-resistant pathogens. Therefore, antimicrobial PDT could be valuable to rapidly reduce the microbial burden during the management of local infections, especially for the antibiotic resistance. A variety of photosensitizers have been examined its efficacy against pathogens. To increase the efficacy of photosensitizers, various drug delivery systems have been developed. Among these carrier systems, liposomes showed their PDT efficacy and safety in delivering photosensitizers. This review is focused on the application of liposomes mediated photodynamic inactivation of bacteria along with the discussion of few of recent patents.
KW - Antibiotic-resistant
KW - Bacteria
KW - Liposome
KW - Photodynamic inactivation
KW - Photodynamic therapy
KW - Photosensitizer
UR - http://www.scopus.com/inward/record.url?scp=84882805746&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84882805746&partnerID=8YFLogxK
U2 - 10.2174/1574891X113089990011
DO - 10.2174/1574891X113089990011
M3 - Review article
C2 - 23550544
AN - SCOPUS:84882805746
SN - 1574-891X
VL - 8
SP - 100
EP - 107
JO - Recent Patents on Anti-Infective Drug Discovery
JF - Recent Patents on Anti-Infective Drug Discovery
IS - 2
ER -
