Liposome-encapsulated anthraquinone improves efficacy and safety in triple negative breast cancer

Thomashire A. George, Max M. Chen, Andreas Czosseck, Hsiang Pei Chen, Hsu Shan Huang, David J. Lundy

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)


Breast cancer is the most common cancer among women and a leading cause of death worldwide. Triple negative breast cancer (TNBC) is a highly aggressive subtype which is the most challenging to treat. Due to heterogeneity and a lack of specific molecular targets, small molecule-based chemotherapy is the preferred course of treatment. However, these drugs have high toxicity due to off-target effects on healthy tissues, and tumors may develop resistance. Here, we present a polyethylene glycol-modified nanoscale liposomal formulation (LipoRV) of a new anthraquinone derivative which has potent effects on multiple TNBC cell lines. LipoRV readily inhibited the cell cycle, induced cell apoptosis, and reduced long-term proliferative potential of TNBC cells. In a xenograft animal model, LipoRV successfully cleared tumors and demonstrated a good safety profile, without detrimental effects on biochemical markers. Finally, RNA sequencing of LipoRV-treated TNBC cells was carried out, indicating that LipoRV may have immunomodulatory properties. These findings demonstrate that a liposomal anthraquinone-based molecule has excellent promise for TNBC therapy in the future.
頁(從 - 到)31-43
期刊Journal of Controlled Release
出版狀態已發佈 - 2月 2022

ASJC Scopus subject areas

  • 藥學科學


深入研究「Liposome-encapsulated anthraquinone improves efficacy and safety in triple negative breast cancer」主題。共同形成了獨特的指紋。