Ligustrazine improves the compensative effect of Akt survival signaling to protect liver Kupffer cells in trauma-hemorrhagic shock rats

Ray Jade Chen, Ming Cheng Chen, Bruce Chi Kang Tsai, Rakesh Roy, Yi Ru Chang, Tso Fu Wang, Wei Wen Kuo, Chia Hua Kuo, Chun Hsu Yao, Chi Cheng Li, Chih Yang Huang

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

Trauma-hemorrhagic shock (THS) is a medical emergency that is encountered by physicians in the emergency department. Chuan Xiong is a traditional Chinese medicine and ligustrazine is a natural compound from it. Ligustrazine improves coronary blood flow and reduces cardiac ischemia in animals through Ca2+ and ATP-dependent vascular relaxation. It also decreases the platelets' bioactivity and reduces reactive oxygen species formation. We hypothesized that ligustrazine could protect liver by decreasing the inflammation response, protein production, and apoptosis in THS rats. Ligustrazine at doses of 100 and 1000 μg/mL was administrated in Kupffer cells isolated from THS rats. The protein expressions were detected via western blot. The THS showed increased inflammation response proteins, mitochondria-dependent apoptosis proteins, and had a compensation effect on the Akt pathway. After ligustrazine treatment, the hemorrhagic shock Kupffer cells decreased inflammatory response and mitochondria-dependent apoptosis and promoted a more compensative effect of the Akt pathway. It suggests ligustrazine reduces inflammation response and mitochondria-dependent apoptosis induced by THS in liver Kupffer cells and promotes more survival effects by elevating the Akt pathway. These findings demonstrate the beneficial effects of ligustrazine against THS-induced hepatic injury, and ligustrazine could be a potential medication to treat the liver injury caused by THS. © 2023 John Wiley & Sons Ltd.
原文英語
頁(從 - 到)1399-1408
頁數10
期刊Chemical Biology and Drug Design
102
發行號6
DOIs
出版狀態已發佈 - 12月 2023

ASJC Scopus subject areas

  • 生物化學
  • 分子醫學
  • 藥理
  • 藥物發現
  • 有機化學

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