Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus

Shu Chen Wang, Chia Hui Lin, Tsan Teng Ou, Cheng Chin Wu, Wen Chan Tsai, Chaur Jong Hu, Hong Wen Liu, Jeng Hsien Yen

研究成果: 雜誌貢獻文章同行評審

21 引文 斯高帕斯(Scopus)


Objective. To investigate the role of ligands for programmed cell death 1 (PD-L) in the pathogenesis of systemic lupus erythematosus (SLE). Methods. One hundred sixty-four patients with SLE and 160 healthy controls were enrolled in our study. The PD-L1 and PD-L2 polymorphisms were determined by polymerase chain reaction (PCR)/direct sequencing or restriction fragment length polymorphism (RFLP)-PCR. Results. The genotype distributions of PD-L2 47103 C/T polymorphisms in patients with SLE were significantly different from those of the controls (p = 0.003). The genotype frequency of PD-L2 47103 T/T, in comparison with 47103 C/C, was significantly increased in patients with SLE when compared with that of the controls (odds ratio 2.5,95% confidence interval 1.4-4.4, p = 0.001). A similar finding could also be found in the allele frequency of PD-L2 47103 T (SLE vs control, OR 1.7, 95% CI 1.3-2.4, p = 0.001). There were no significant differences in the genotype and allele frequencies of PD-L1 polymorphisms between the patients and controls. Conclusion. PD-L2 47103 T may be associated with susceptibility to SLE in Taiwan.

頁(從 - 到)721-725
期刊Journal of Rheumatology
出版狀態已發佈 - 4月 2007

ASJC Scopus subject areas

  • 風濕病
  • 免疫學


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