Leukocytosis in polycythemia vera and splenomegaly in essential thrombocythemia are independent risk factors for hemorrhage

Yi Sheng Chou, Jyh Pyng Gau, Yuan Bin Yu, Jih Tung Pai, Liang Tsai Hsiao, Jin Hwang Liu, Ying Chung Hong, Chun Yu Liu, Ching Fen Yang, Po Min Chen, Tzeon Jye Chiou, Cheng Hwai Tzeng

研究成果: 雜誌貢獻文章同行評審

17 引文 斯高帕斯(Scopus)

摘要

Background: Long-term outcomes are favorable for patients with polycythemia vera (PV) and for patients with essential thrombocythemia (ET). However, hemorrhage is a significant cause of morbidity and mortality in those patients. Methods: We retrospectively recruited 247 patients who had received a diagnosis of PV (n = 101) or ET (n = 146) during the period 2001-2010. Results: After a median follow-up period of 36.2 months, the cumulative incidence of hemorrhage was 39.6% in patients with PV (6.2% per person-year) and 29.7% in patients with ET (5.9% person-years). Episodes of major bleeding occurred in 9.9% of patients with PV and in 14.4% of patients with ET. Overall survival was significantly shorter among patients with hemorrhage than among those without said complication (P < 0.001 for overall patients; P = 0.002 for patients with PV; P = 0.026 for patients with ET). In the univariate analysis, age ≥60 yr (OR: 4.77, P = 0.046) and WBC ≥ 16 × 109/L (OR: 4.15, P = 0.010) were predictors of hemorrhage in patients with PV, and age ≥60 yr (OR: 3.25, P = 0.040), WBC ≥ 16 × 109/L (OR: 2.89, P = 0.024), albumin <4.0 g/dL (OR: 4.10, P = 0.002), and splenomegaly (OR: 5.19, P = 0.002) were predictors of hemorrhage in patients with ET. Multivariate analysis showed that WBC ≥ 16 × 109/L was the only significant risk factor for hemorrhage in patients with PV (OR: 3.51, P = 0.026) and that splenomegaly was the only risk factor for hemorrhage in patients with ET (OR: 3.00, P = 0.048). Conclusion: Leukocytosis in PV and splenomegaly in ET are independent risk factors for hemorrhage.

原文英語
頁(從 - 到)228-236
頁數9
期刊European Journal of Haematology
90
發行號3
DOIs
出版狀態已發佈 - 3月 2013
對外發佈

ASJC Scopus subject areas

  • 血液學

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