TY - JOUR
T1 - Laparoscopic surgery in polycystic ovary syndrome
T2 - Reproductive and metabolic effects
AU - Seow, Kok Min
AU - Juan, Chi Chang
AU - Hwang, Jiann Loung
AU - Ho, Low Tone
PY - 2008/1
Y1 - 2008/1
N2 - Polycystic ovary syndrome (PCOS) is the most common cause of chronic anovulation. Clomiphene citrate (CC) is the first-line treatment for ovulation induction for infertile women with PCOS. In CC-resistant women, a particular surgical method, laparoscopic ovarian drilling (LOD), has been proposed in recent years as an alternative treatment. LOD produces overall spontaneous ovulation and pregnancy rates of 30 to 90% and 13 to 88%, respectively, for CC-resistant PCOS women. The mechanism of LOD is still unknown. The reduction of serum androgen level is believed to be the possible mechanism of LOD to improve spontaneous ovulation and promote fertility in women with PCOS. In addition, LOD may cause a significant reduction in serum luteinizing hormone and insulin levels. However, it should be kept in mind that postoperative adhesion is the most common adverse effect of LOD, and more punctures may be responsible for premature ovarian failure.
AB - Polycystic ovary syndrome (PCOS) is the most common cause of chronic anovulation. Clomiphene citrate (CC) is the first-line treatment for ovulation induction for infertile women with PCOS. In CC-resistant women, a particular surgical method, laparoscopic ovarian drilling (LOD), has been proposed in recent years as an alternative treatment. LOD produces overall spontaneous ovulation and pregnancy rates of 30 to 90% and 13 to 88%, respectively, for CC-resistant PCOS women. The mechanism of LOD is still unknown. The reduction of serum androgen level is believed to be the possible mechanism of LOD to improve spontaneous ovulation and promote fertility in women with PCOS. In addition, LOD may cause a significant reduction in serum luteinizing hormone and insulin levels. However, it should be kept in mind that postoperative adhesion is the most common adverse effect of LOD, and more punctures may be responsible for premature ovarian failure.
KW - Clomiphene citrate-resistant
KW - Laparoscopic ovarian drilling
KW - Ovulation rate
KW - Polycystic ovary syndrome
KW - Pregnancy rate
UR - http://www.scopus.com/inward/record.url?scp=38149140122&partnerID=8YFLogxK
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U2 - 10.1055/s-2007-992930
DO - 10.1055/s-2007-992930
M3 - Article
C2 - 18181088
AN - SCOPUS:38149140122
SN - 1526-8004
VL - 26
SP - 101
EP - 110
JO - Seminars in Reproductive Medicine
JF - Seminars in Reproductive Medicine
IS - 1
ER -