@article{d3292704ae7d40328f60b055ea77960c,
title = "Lactoferrin attenuated urban particulate matter-induced nephrotoxicity by regulating the CSF2/CENPE axis",
abstract = "Several epidemiological studies regarding the adverse effect of air pollution have notably accelerated in recent years. Urban particulate matter (PM) gains access to the respiratory system and translocates into the circulation to affect several tissues, such as the liver and kidneys. Lactoferrin is a substance belonging to the non-heme iron-binding glycoprotein which is present in breast milk and other exocrine fluids. Lactoferrin is protective against many pathophysiological conditions. In the present study, we explored the potential influence of lactoferrin on PM-induced nephrotoxicity. We found that lactoferrin rescued PM-induced cell death but did not affect apoptosis in human kidney cells. Lactoferrin decreased necroptosis and fibrosis but increased autophagy in human kidney cells. Furthermore, the gene expression profiles of PM and lactoferrin were analyzed by RNA sequencing. The transcriptional profiles were uploaded and analyzed by ingenuity pathway analysis software and gene set enrichment analysis. The results showed that the crucial role of the CSF2/CENPE pathway was involved in human kidney cells treated with PM and lactoferrin. In a mouse model, lactoferrin ameliorates PM-induced nephrotoxicity by regulating necroptosis, fibrosis, autophagy and the CSF2/CENPE axis. In summary, these findings showed that lactoferrin could be a novel therapeutic or preventive agent for renal disorders caused by airborne PM pollution.",
keywords = "Autophagy, Lactoferrin, Necroptosis, Nephrotoxicity, Particulate matter",
author = "Liu, {Wen Chih} and Chiu, {Hui Wen} and Chou, {Chu Lin} and Chiu, {Yu Jhe} and Lee, {Yu Hsuan}",
note = "Funding Information: This study was supported by the Ministry of Science and Technology, Taiwan (MOST 109-2314-B-038-078-MY3 , MOST 110-2314-B-039-018 , MOST 111-2314-B-039-021 and MOST 111-2314-B-038-154 ), China Medical University , Taichung, Taiwan ( CMU111-N-27 ) and Taipei Hospital, Ministry of Health and Welfare, Taiwan (Grant no. 202208 ). Experiments and data analysis were performed in part through the use of the Medical Research Core Facilities Center, Office of Research & Development at China Medical University , Taichung, Taiwan. Funding Information: This study was supported by the Ministry of Science and Technology, Taiwan (MOST109-2314-B-038-078-MY3, MOST 110-2314-B-039-018, MOST 111-2314-B-039-021 and MOST 111-2314-B-038-154), China Medical University, Taichung, Taiwan (CMU111-N-27) and Taipei Hospital, Ministry of Health and Welfare, Taiwan (Grant no. 202208). Experiments and data analysis were performed in part through the use of the Medical Research Core Facilities Center, Office of Research & Development at China Medical University, Taichung, Taiwan. Publisher Copyright: {\textcopyright} 2022",
year = "2023",
month = feb,
day = "1",
doi = "10.1016/j.envpol.2022.120871",
language = "English",
volume = "318",
journal = "Environmental Pollution",
issn = "0269-7491",
publisher = "Elsevier Ltd",
}
