Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana

Chin Lin Hsien; Mei Hwei Tseng; Ryh Nan Pan; Jang Yang Chang; Ching Chuan Kuo; Zong-Huei Li; Yueh Hsiung Kuo

doi:10.1016/j.tetlet.2010.11.101

Labdanecaryophyllic acid, a novel cytotoxic C₃₅ terpenoid from Calocedrus macrolepis var. formosana

Chin Lin Hsien, Mei Hwei Tseng, Ryh Nan Pan, Jang Yang Chang, Ching Chuan Kuo, Zong-Huei Li, Yueh Hsiung Kuo

生藥學研究所

研究成果: 雜誌貢獻 › 文章 › 同行評審

6 引文斯高帕斯（Scopus）

摘要

Chemical investigation of the bark of Calocedrus macrolepis var. formosana, an endemic tree in Taiwan, has led to the isolation of a novel terpenoid 1. Compound 1 with a rare C35 skeleton constructed by a diterpene and a sesquiterpene moieties. Its structure was elucidated by spectroscopic interpretations. The anti-proliferation activity of 1 against human oral epidermoid carcinoma KB cells was evaluated, and the IC50 value was determined to be 9.2 ± 0.4 μM.

原文	英語
頁（從 - 到）	515-517
頁數	3
期刊	Tetrahedron Letters
卷	52
發行號	4
DOIs	https://doi.org/10.1016/j.tetlet.2010.11.101
出版狀態	已發佈 - 1月 26 2011

ASJC Scopus subject areas

生物化學
有機化學
藥物發現

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10.1016/j.tetlet.2010.11.101

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引用此

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title = "Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana",

abstract = "Chemical investigation of the bark of Calocedrus macrolepis var. formosana, an endemic tree in Taiwan, has led to the isolation of a novel terpenoid 1. Compound 1 with a rare C35 skeleton constructed by a diterpene and a sesquiterpene moieties. Its structure was elucidated by spectroscopic interpretations. The anti-proliferation activity of 1 against human oral epidermoid carcinoma KB cells was evaluated, and the IC50 value was determined to be 9.2 ± 0.4 μM.",

keywords = "Calocedrus macrolepis, Cupressaceae, Terpenoid, X-ray crystallography",

author = "Hsien, {Chin Lin} and Tseng, {Mei Hwei} and Pan, {Ryh Nan} and Chang, {Jang Yang} and Kuo, {Ching Chuan} and Zong-Huei Li and Kuo, {Yueh Hsiung}",

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T1 - Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana

AU - Hsien, Chin Lin

AU - Tseng, Mei Hwei

AU - Pan, Ryh Nan

AU - Chang, Jang Yang

AU - Kuo, Ching Chuan

AU - Li, Zong-Huei

AU - Kuo, Yueh Hsiung

PY - 2011/1/26

Y1 - 2011/1/26

N2 - Chemical investigation of the bark of Calocedrus macrolepis var. formosana, an endemic tree in Taiwan, has led to the isolation of a novel terpenoid 1. Compound 1 with a rare C35 skeleton constructed by a diterpene and a sesquiterpene moieties. Its structure was elucidated by spectroscopic interpretations. The anti-proliferation activity of 1 against human oral epidermoid carcinoma KB cells was evaluated, and the IC50 value was determined to be 9.2 ± 0.4 μM.

AB - Chemical investigation of the bark of Calocedrus macrolepis var. formosana, an endemic tree in Taiwan, has led to the isolation of a novel terpenoid 1. Compound 1 with a rare C35 skeleton constructed by a diterpene and a sesquiterpene moieties. Its structure was elucidated by spectroscopic interpretations. The anti-proliferation activity of 1 against human oral epidermoid carcinoma KB cells was evaluated, and the IC50 value was determined to be 9.2 ± 0.4 μM.

KW - Calocedrus macrolepis

KW - Cupressaceae

KW - Terpenoid

KW - X-ray crystallography

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DO - 10.1016/j.tetlet.2010.11.101

M3 - Article

AN - SCOPUS:78650519367

SN - 0040-4039

VL - 52

SP - 515

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 4

ER -

Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana

摘要

ASJC Scopus subject areas

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其它文件與鏈接

指紋

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Labdanecaryophyllic acid, a novel cytotoxic C₃₅ terpenoid from Calocedrus macrolepis var. formosana