摘要
原文 | 英語 |
---|---|
頁(從 - 到) | 904-911 |
頁數 | 8 |
期刊 | Process Biochemistry |
卷 | 51 |
發行號 | 7 |
DOIs | |
出版狀態 | 已發佈 - 2016 |
指紋
深入研究「L-Lysine regulates tumor necrosis factor-alpha and matrix metalloproteinase-3 expression in human osteoarthritic chondrocytes」主題。共同形成了獨特的指紋。引用此
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於: Process Biochemistry, 卷 51, 編號 7, 2016, p. 904-911.
研究成果: 雜誌貢獻 › 文章 › 同行評審
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TY - JOUR
T1 - L-Lysine regulates tumor necrosis factor-alpha and matrix metalloproteinase-3 expression in human osteoarthritic chondrocytes
AU - Huang, Teng Le
AU - Wu, Chang Chin
AU - Yu, Jia-shing
AU - Sumi, Shoichiro
AU - Yang, K.-C.
N1 - Export Date: 24 August 2016 CODEN: PBCHE 通訊地址: Yang, K.-C.; School of Dental Technology, College of Oral Medicine, Taipei Medical University, No. 250, Wuxing St, Taiwan; 電子郵件: [email protected] 參考文獻: Wang, Y., Xu, D., Long, L., Deng, X., Tao, R., Huang, G., Correlation between plasma, synovial fluid and articular cartilage Interleukin-18 with radiographic severity in 33 patients with osteoarthritis of the knee (2014) Clin. Exp. Med., 14 (3), pp. 297-304; Berenbaum, F., Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!) (2013) Osteoarthr. Cartil., 21 (1), pp. 16-21; Bartok, B., Firestein, G.S., Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis (2010) Immunol. Rev., 233 (1), pp. 233-255; Hoff, P., Buttgereit, F., Burmester, G.R., Jakstadt, M., Gaber, T., Andreas, K., Matziolis, G., Röhner, E., Osteoarthritis synovial fluid activates pro-inflammatory cytokines in primary human chondrocytes (2013) Int. 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PY - 2016
Y1 - 2016
N2 - Inflammatory cytokines, which induce articular chondrocytes to undergo hypertrophic transformation and apoptotic death, mediate osteoarthritis (OA) progression. l-Lysine (Lys) are involved in multiple biological processes including inflammatory regulation. However, rare research has addressed the effects of Lys on human chondrocytes. In this study, chondrocytes were isolated from articular cartilage of OA patients, stimulated with interleukin-1β (IL-1β) and subsequently supplied with Lys. Lys improved hypertrophic transformation of chondrocytes. However, the proliferation of IL-1β-stimulated chondrocytes was still faster than that of unstimulated cells even under providing Lys supplement. The mRNA levels of tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-9 (MMP-9) decreased when normal chondrocytes treated with Lys. IL-1β stimulation upregulated type I collagen, type X collagen, IL-1β, TNF-α, MMP-3, MMP-9 and downregulated aggrecan, type II collagen mRNA levels. On the contrary, Lys downregulated TNF-α, MMP-3 levels, restored aggrecan and collagens expressions, and further increased the aggrecan/type I collagen and type II collagen/type I collagen rations in IL-1β-stimulated chondrocytes. In addition, Lys treatment decreased the protein productions of TNF-α and MMP-3 in stimulated cells. Our results suggest that Lys may modulate matrix proteins, inflammatory and catabolic cytokines in OA chondrocytes. © 2016 Elsevier Ltd.
AB - Inflammatory cytokines, which induce articular chondrocytes to undergo hypertrophic transformation and apoptotic death, mediate osteoarthritis (OA) progression. l-Lysine (Lys) are involved in multiple biological processes including inflammatory regulation. However, rare research has addressed the effects of Lys on human chondrocytes. In this study, chondrocytes were isolated from articular cartilage of OA patients, stimulated with interleukin-1β (IL-1β) and subsequently supplied with Lys. Lys improved hypertrophic transformation of chondrocytes. However, the proliferation of IL-1β-stimulated chondrocytes was still faster than that of unstimulated cells even under providing Lys supplement. The mRNA levels of tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-9 (MMP-9) decreased when normal chondrocytes treated with Lys. IL-1β stimulation upregulated type I collagen, type X collagen, IL-1β, TNF-α, MMP-3, MMP-9 and downregulated aggrecan, type II collagen mRNA levels. On the contrary, Lys downregulated TNF-α, MMP-3 levels, restored aggrecan and collagens expressions, and further increased the aggrecan/type I collagen and type II collagen/type I collagen rations in IL-1β-stimulated chondrocytes. In addition, Lys treatment decreased the protein productions of TNF-α and MMP-3 in stimulated cells. Our results suggest that Lys may modulate matrix proteins, inflammatory and catabolic cytokines in OA chondrocytes. © 2016 Elsevier Ltd.
KW - Chondrocyte
KW - Hypertrophy
KW - Inflammatory cytokine
KW - l-lysine
KW - Osteoarthritis
KW - Amino acids
KW - Cartilage
KW - Collagen
KW - Glycoproteins
KW - Macrophages
KW - Proteins
KW - Tumors
KW - Chondrocytes
KW - Cytokines
KW - l-Lysine
KW - Body fluids
U2 - 10.1016/j.procbio.2016.04.009
DO - 10.1016/j.procbio.2016.04.009
M3 - Article
SN - 1359-5113
VL - 51
SP - 904
EP - 911
JO - Process Biochemistry
JF - Process Biochemistry
IS - 7
ER -