@article{bb57df6feaa847678b3761822ca976c6,
title = "KCNQ1 variants associate with hypertension in type 2 diabetes and affect smooth muscle contractility in vitro",
abstract = "KCNQ1 encodes a potassium voltage-gated channel and represents a susceptibility locus for type 2 diabetes mellitus (T2DM). Here, we explored the association between KCNQ1 polymorphisms and hypertension risk in individuals with T2DM, as well as the role of KCNQ1 in vascular smooth muscle cell contraction in vitro. To investigate the relationship between KCNQ1 and the risk of developing hypertension in patients with T2DM, we divided the T2DM cohort into hypertension (n=452) and non-hypertension (n=541) groups. The Mann-Whitney U test, chi-square test, and multivariate regression analyses were used to assess the clinical characteristics and genotypic frequencies. In vitro studies utilized the rat aortic smooth muscle A10 cell line. Patients in the hypertension group were significantly older at the time of enrollment and had higher levels of body mass index, waist-to-hip ratio, and triglyceride than those in the non-hypertension group. The KCNQ1 rs3864884 and rs12576239 genetic variants were associated with hypertension in T2DM. KCNQ1 expression was lower in the individuals with the CC versus the CT and TT genotypes. Smooth muscle cell contractility was inhibited by treatment with a KCNQ1 inhibitor. These results suggest that KCNQ1 might be associated with hypertension in individuals with T2DM.",
keywords = "KCNQ1, genetic variants, hypertension, muscle contractility, type 2 diabetes",
author = "Huang, {Kuo Chin} and Li, {Te Mao} and Xiang Liu and Chen, {Jin Hua} and Chien, {Wen Kuei} and Shiao, {Yi Tzone} and Hsinyi Tsang and Lin, {Ting Hsu} and Liao, {Chiu Chu} and Huang, {Shao Mei} and Li, {Ju Pi} and Lin, {Cheng Wen} and Lin, {Jung Chun} and Lin, {Chih Chien} and Lai, {Chih Ho} and Cheng, {Chi Fung} and Liang, {Wen Miin} and Hung, {Chien Hui} and Chen, {Ching Chu} and Lin, {Ying Ju} and Tsai, {Fuu Jen}",
note = "Funding Information: The authors wish to thank the China Medical University under the Aim for the Top University Plan of the Ministry of Education, Taiwan, and the Department of Internal Medicine, China Medical University Hospital, for administrative assistance. The authors also thank Dr. Kuan-Teh Jeang and Dr. Willy W. L. Hong for technical help and suggestions. The authors have no disclosures or other conflicts of interest to report. Funding Information: Ministry of Science and Technology, Grant number: MOST 103-2320-B-039-006- MY3; National Science Council, Grant number: NSC 102-2314-B-039-011-MY3; China Medical University, Grant number: CMU102-PH-01; China Medical University Hospital, Grant number: DMR-105-031; China Medical University Hospital, Grant number: DMR-105-098 Publisher Copyright: {\textcopyright} 2017 Wiley Periodicals, Inc.",
year = "2017",
month = dec,
doi = "10.1002/jcp.25775",
language = "English",
volume = "232",
pages = "3309--3316",
journal = "Journal of Cellular Physiology",
issn = "0021-9541",
publisher = "Wiley-Liss Inc.",
number = "12",
}
