@article{0c5e1ed3145747a1ae1c2eaf41ae28f8,
title = "Investigation of bone growth in additive-manufactured pedicle screw implant by using Ti-6Al-4V and bioactive glass powder composite",
abstract = "In this study, we optimized the geometry and composition of additive-manufactured pedicle screws. Metal powders of titanium-aluminum-vanadium (Ti-6Al-4V) were mixed with reactive glass-ceramic biomaterials of bioactive glass (BG) powders. To optimize the geometry of pedicle screws, we applied a novel numerical approach to proposing the optimal shape of the healing chamber to promote biological healing. We examined the geometry and composition effects of pedicle screw implants on the interfacial autologous bone attachment and bone graft incorporation through in vivo studies. The addition of an optimal amount of BG to Ti-6Al-4V leads to a lower elastic modulus of the ceramic-metal composite material, effectively reducing the stress-shielding effects. Pedicle screw implants with optimal shape design and made of the composite material of Ti-6Al-4V doped with BG fabricated through additive manufacturing exhibit greater osseointegration and a more rapid bone volume fraction during the fracture healing process 120 days after implantation, per in vivo studies.",
keywords = "Additive manufacturing, Bioactive glass, Osseointegration, Pedicle screw implant, Stress-shielding effect, X-ray tomography",
author = "Lam, {Tu Ngoc} and Trinh, {Minh Giam} and Huang, {Chih Chieh} and Kung, {Pei Ching} and Huang, {Wei Chin} and Wei Chang and Lia Amalia and Chin, {Hsu Hsuan} and Tsou, {Nien Ti} and Shih, {Shao Ju} and Chen, {San Yuan} and Wang, {Chun Chieh} and Tsai, {Pei I.} and Wu, {Meng Huang} and Huang, {E. Wen}",
note = "Funding Information: Funding: EWH appreciates the support from Ministry of Science and Technology (MOST) Programs 107-2628-E-009-001-MY3, 107-2218-E-009-003, and 108-2221-E-009-131-MY4. This work was financially supported by the “Center for the Semiconductor Technology Research” from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan. In addition, this study was supported in part by the Ministry of Science and Technology, Taiwan, under grant MOST 109-2634-F-009-029. We appreciate the support from Taipei Medical University TMU109-AE1-B01. We thank the Industrial Technology Research Institute (ITRI) Programs 109A502, F301AR7Z50, G301AR7Z50, and GM5400J000TNL. We acknowledge the MOST, Taiwan, for financial support through grant no. MOST-108-2739-M-213-001 from National Synchrotron Radiation Research Center (NSRRC) Neutron Cultivation Program, in providing the resources (facility/instrument/expertise) used in this work. Funding Information: Acknowledgments: We greatly appreciate the beam time and help from the BL01B Nano-Transmission X-ray Microscopy, Taiwan Photon Source (TPS) 21A X-ray Nanodiffraction and TPS 23A X-ray Nanoprobe end-stations of the National Synchrotron Radiation Research Center (NSRRC). The authors specially thank Shin-Yi Huang from the ITRI for preparation of bone samples. We appreciate the help of Tzu-Hung Lin from the ITRI in analyzing X-ray micro-computed tomography. The authors would like to acknowledge the Laboratory Animal Center at TMU and the PigModel Animal Technology for technical support in the porcine experiment. Research conducted at ORNL{\textquoteright}s Spallation Neutron Source was sponsored by the Scientific User Facilities Division, Office of Basic Energy Sciences, US Department of Energy. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = oct,
doi = "10.3390/ijms21207438",
language = "English",
volume = "21",
pages = "1--13",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI AG",
number = "20",
}