Intravesical delivery of 5-aminolevulinic acid from water-in-oil nano/submicron-emulsion systems

Jia You Fang, Pao Chu Wu, Chia Lang Fang, Chao Huang Chen

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)


The present work reports on the development of water-in-oil (w/o) emulsions for the intravesical administration of 5-aminolevulinic acid (ALA). The physicochemical properties of droplet size, zeta potential, and viscosity of the emulsions are characterized and the ability of the emulsions to release ALA following in vitro application is tested. The delivery systems are administered intravesically for 1 and 3 h in rats to examine the drug accumulation in bladder tissue. The mean size and zeta potential of the emulsions are 50-200nm and -3 to -14 mV, respectively. The loading of ALA into the emulsions resulted in a slower and sustained release. The release extent was found to be inversely related to the droplet size of the emulsions. The emulsions did not increase the drug permeation into tissues during short exposure duration (1 h). When the dwell time was extended to 3 h, the systems showed a 2.7-fold increase in the ALA concentration in the bladder wall. Images of confocal laser scanning microscopy demonstrated a higher and deeper fluorescence signal, with emulsion administration, as compared to the aqueous control. Intravesical emulsion delivery provides a significant advantage for drugs targeting bladder tissues.

頁(從 - 到)2375-2385
期刊Journal of Pharmaceutical Sciences
出版狀態已發佈 - 5月 2010

ASJC Scopus subject areas

  • 藥學科學


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