TY - JOUR
T1 - Intradermal Injection of Tranexamic Acid for the Treatment of Adult Melasma
T2 - A Systematic Review and Meta-Analysis of Randomized Controlled Trials
AU - Chen, Ling Ya
AU - Kang, Yi No
AU - Hoang, Khanh Dinh
AU - Chen, Kee Hsin
AU - Chen, Chiehfeng
N1 - Publisher Copyright:
© American Academy of Facial Plastic and Reconstructive Surgery, Inc.
PY - 2024
Y1 - 2024
N2 - Background: Melasma is a chronic skin pigmentation disorder, and intradermal injection of tranexamic acid (TXA) is an effective treatment option for melasma with limited comparative efficacy studies. Objectives: To compare the effectiveness of TXA injections with other treatment modalities for patients with melasma, as measured by Melasma Area and Severity Index (MASI). Methods: A total of 17 eligible randomized controlled trials were included in the meta-analysis. The MASI and the modified MASI served as the primary outcome measures of treatment effectiveness. Patient satisfaction was also evaluated. Results: Among the various administration routes for TXA, intradermal injection and microneedling demonstrated superior effectiveness, followed by oral administration and topical application. As for patient satisfaction, oral administration outperformed the injection method, whereas topical administration significantly underperformed injection. Furthermore, TXA injections were more effective than the majority of non-TXA standard treatments for melasma. Conclusions: This meta-analysis and systematic review suggested that intradermal TXA injection is an effective alternative for melasma treatment, with potential advantages over other administration routes.
AB - Background: Melasma is a chronic skin pigmentation disorder, and intradermal injection of tranexamic acid (TXA) is an effective treatment option for melasma with limited comparative efficacy studies. Objectives: To compare the effectiveness of TXA injections with other treatment modalities for patients with melasma, as measured by Melasma Area and Severity Index (MASI). Methods: A total of 17 eligible randomized controlled trials were included in the meta-analysis. The MASI and the modified MASI served as the primary outcome measures of treatment effectiveness. Patient satisfaction was also evaluated. Results: Among the various administration routes for TXA, intradermal injection and microneedling demonstrated superior effectiveness, followed by oral administration and topical application. As for patient satisfaction, oral administration outperformed the injection method, whereas topical administration significantly underperformed injection. Furthermore, TXA injections were more effective than the majority of non-TXA standard treatments for melasma. Conclusions: This meta-analysis and systematic review suggested that intradermal TXA injection is an effective alternative for melasma treatment, with potential advantages over other administration routes.
UR - http://www.scopus.com/inward/record.url?scp=85210918373&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85210918373&partnerID=8YFLogxK
U2 - 10.1089/fpsam.2024.0187
DO - 10.1089/fpsam.2024.0187
M3 - Article
AN - SCOPUS:85210918373
SN - 2689-3614
JO - Facial Plastic Surgery and Aesthetic Medicine
JF - Facial Plastic Surgery and Aesthetic Medicine
ER -