@article{7bb1fd735b5e4293b153abbf24bfbc5c,
title = "Interleukin 8 may predict surgical necrotizing enterocolitis in infants born less than 1500 g",
abstract = "Necrotizing enterocolitis (NEC) often leads to gastrointestinal emergency resulting high mortality in very low birth weight infants (VLBWIs) requiring surgery. To date, few studies have explored the role of serum cytokines in the development of feeding intolerance (FI) or NEC outcomes in VLBWIs. Infants born weighing <1500 g or of 32 weeks of gestational age were prospectively enrolled from May 2018 to Dec 2019. We measured several cytokines routinely within 72 h of life, even before NEC-like symptoms developed. NEC or FI group comprised 17 (27.4\%) infants, and 6 (9.7\%) infants had surgical NEC. The gestational age and birth weight were significantly lower in the NEC or FI group with more prematurity-related complications. The surgical NEC group also demonstrated significantly lower gestational age and birth weight along with more infants experiencing refractory hypotension within a 1 week of life, pulmonary hypertension, and patent ductus arteriosus. IL-10 levels were significantly higher in the NEC or FI group, whereas IL-8 levels were significantly higher in the infants with surgical NEC. Our findings indicated to IL-8 can predict surgical NEC while increased IL-10 can predict NEC development in VLBWIs.",
keywords = "Cytokines, Enterocolitis, necrotizing, Feeding intolerance, IL-8, IL-10, Very low birth weight infants",
author = "\{Department of Pediatrics, Seoul St. Mary's Hospital, Catholic Medical College, Catholic University, Seoul, Korea\} and Seo, \{Yu mi\} and Lin, \{Yen Kuang\} and Im, \{Soo Ah\} and Sung, \{In Kyung\} and Youn, \{Young Ah\}",
note = "Funding Information: The authors declare the following financial interests/personal relationships are not considered as potential competing interests: The authors are fully aware that this research was supported by a grant from the Catholic Medical Center Research Foundation made in the 2018 program year (5-2018-B0001-00214). We, each author listed on the manuscript, have seen and approved the submission of this version of the manuscript and have no conflicts of interest. Funding Information: This research was financially supported by the Catholic Medical Center Research Foundation made in the program year of 2018 ( 5-2018-B0001-00214 ). Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2021",
month = jan,
doi = "10.1016/j.cyto.2020.155343",
language = "English",
volume = "137",
journal = "Cytokine",
issn = "1043-4666",
publisher = "Academic Press",
}
