Interleukin-18 is a strong predictor of hospitalization in haemodialysis patients

Chih Kang Chiang, Shih Ping Hsu, Mei Fen Pai, Yu Sen Peng, Tai I. Ho, Shing Hwa Liu, Kuan Yu Hung, Tun Jun Tsai

研究成果: 雜誌貢獻文章同行評審

44 引文 斯高帕斯(Scopus)

摘要

Background. Morbidity and mortality rates are high among patients with end-stage renal disease (ESRD), and recent evidence suggests that this may be linked to inflammation. Current research has also demonstrated the crucial involvement of interleukin-18 (IL-18) in inflammation. In agreement, the activity of IL-18 has been markedly up-regulated in ESRD patients. However, it has not been established whether elevated plasma IL-18 predicts outcome in haemodialysis (HD) patients. Methods. To determine whether plasma IL-18 predicts overall hospitalization, we studied 184 ESRD patients (62% males, 58.5 ± 1.0 years of age) undergoing maintenance HD treatment. The patients were followed for 12 months and were stratified by the tertiles of plasma IL-18 levels. Classic factors, such as age, body mass index, duration of HD, nutritional and inflammatory parameters, co-morbidity, dialysis adequacy, and lipid status were entered into a Cox regression model to predict hospitalization. The Kaplan-Meier method was used to analyse the cumulative proportion of hospitalization-free events. Results. Significantly different hospitalization days and frequencies (P < 0.05) were observed when patients were divided according to tertiles of plasma IL-18 levels. Patients were stratified according to IL-18 tertiles and analysed separately according to the hospitalization-free period. In the Kaplan-Meier model, the upper tertile of IL-18 had the highest probability of a hospitalization event during the entire follow-up period (P log rank = 0.027). In the Cox proportional hazard model, the relative risk for first hospital admission for each increase in Ln IL-18 (pg/ml) concentration was associated with a 1.709 (95% CI, 1.114 to 2.620; P = 0.014) increase in the risk for future hospitalization events. Conclusions. The present study demonstrated a strong predictive value of elevated IL-18 levels for poor outcome in HD patients.
原文英語
頁(從 - 到)2810-2815
頁數6
期刊Nephrology Dialysis Transplantation
19
發行號11
DOIs
出版狀態已發佈 - 11月 2004
對外發佈

ASJC Scopus subject areas

  • 腎臟病學
  • 移植

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