Interactive deciphering electron-shuttling characteristics of Coffea arabica leaves and potential bioenergy-steered anti-SARS-CoV-2 RdRp inhibitor via microbial fuel cells

Po Wei Tsai; Lemmuel L. Tayo; Jasmine U. Ting; Cheng Yang Hsieh; Chia Jung Lee; Chih Ling Chen; Hsiao Chuan Yang; Hsing Yu Tsai; Chung Chuan Hsueh; Bor Yann Chen

doi:10.1016/j.indcrop.2022.115944

Interactive deciphering electron-shuttling characteristics of Coffea arabica leaves and potential bioenergy-steered anti-SARS-CoV-2 RdRp inhibitor via microbial fuel cells

Po Wei Tsai, Lemmuel L. Tayo, Jasmine U. Ting, Cheng Yang Hsieh, Chia Jung Lee, Chih Ling Chen, Hsiao Chuan Yang, Hsing Yu Tsai, Chung Chuan Hsueh, Bor Yann Chen

研究成果: 雜誌貢獻 › 文章 › 同行評審

13 引文斯高帕斯（Scopus）

摘要

Due to the pandemics of COVID-19, herbal medicine has recently been explored for possible antiviral treatment and prevention via novel platform of microbial fuel cells. It was revealed that Coffea arabica leaves was very appropriate for anti-COVID-19 drug development. Antioxidant and anti-inflammatory tests exhibited the most promising activities for C. arabica ethanol extracts and drying approaches were implemented on the leaf samples prior to ethanol extraction. Ethanol extracts of C. arabica leaves were applied to bioenergy evaluation via DC-MFCs, clearly revealing that air-dried leaves (CA-A-EtOH) exhibited the highest bioenergy-stimulating capabilities (ca. 2.72 fold of power amplification to the blank). Furthermore, molecular docking analysis was implemented to decipher the potential of C. arabica leaves metabolites. Chlorogenic acid (−6.5 kcal/mol) owned the highest binding affinity with RdRp of SARS-CoV-2, showing a much lower average RMSF value than an apoprotein. This study suggested C. arabica leaves as an encouraging medicinal herb against SARS-CoV-2.

原文	英語
文章編號	115944
期刊	Industrial Crops and Products
卷	191
DOIs	https://doi.org/10.1016/j.indcrop.2022.115944
出版狀態	已發佈 - 1月 2023

ASJC Scopus subject areas

農學與作物科學

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10.1016/j.indcrop.2022.115944

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引用此

Tsai, P. W., Tayo, L. L., Ting, J. U., Hsieh, C. Y., Lee, C. J., Chen, C. L., Yang, H. C., Tsai, H. Y., Hsueh, C. C., & Chen, B. Y. (2023). Interactive deciphering electron-shuttling characteristics of Coffea arabica leaves and potential bioenergy-steered anti-SARS-CoV-2 RdRp inhibitor via microbial fuel cells. Industrial Crops and Products, 191, 文章 115944. https://doi.org/10.1016/j.indcrop.2022.115944

Tsai, PW, Tayo, LL, Ting, JU, Hsieh, CY, Lee, CJ, Chen, CL, Yang, HC, Tsai, HY, Hsueh, CC & Chen, BY 2023, 'Interactive deciphering electron-shuttling characteristics of Coffea arabica leaves and potential bioenergy-steered anti-SARS-CoV-2 RdRp inhibitor via microbial fuel cells', Industrial Crops and Products, 卷 191, 115944. https://doi.org/10.1016/j.indcrop.2022.115944

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title = "Interactive deciphering electron-shuttling characteristics of Coffea arabica leaves and potential bioenergy-steered anti-SARS-CoV-2 RdRp inhibitor via microbial fuel cells",

abstract = "Due to the pandemics of COVID-19, herbal medicine has recently been explored for possible antiviral treatment and prevention via novel platform of microbial fuel cells. It was revealed that Coffea arabica leaves was very appropriate for anti-COVID-19 drug development. Antioxidant and anti-inflammatory tests exhibited the most promising activities for C. arabica ethanol extracts and drying approaches were implemented on the leaf samples prior to ethanol extraction. Ethanol extracts of C. arabica leaves were applied to bioenergy evaluation via DC-MFCs, clearly revealing that air-dried leaves (CA-A-EtOH) exhibited the highest bioenergy-stimulating capabilities (ca. 2.72 fold of power amplification to the blank). Furthermore, molecular docking analysis was implemented to decipher the potential of C. arabica leaves metabolites. Chlorogenic acid (−6.5 kcal/mol) owned the highest binding affinity with RdRp of SARS-CoV-2, showing a much lower average RMSF value than an apoprotein. This study suggested C. arabica leaves as an encouraging medicinal herb against SARS-CoV-2.",

keywords = "Biorefinery, Chlorogenic acid, Coffea arabica leaves, COVID-19, Microbial fuel cells, RdRp",

author = "Tsai, {Po Wei} and Tayo, {Lemmuel L.} and Ting, {Jasmine U.} and Hsieh, {Cheng Yang} and Lee, {Chia Jung} and Chen, {Chih Ling} and Yang, {Hsiao Chuan} and Tsai, {Hsing Yu} and Hsueh, {Chung Chuan} and Chen, {Bor Yann}",

note = "Funding Information: The authors sincerely appreciate financial supports ( MOST 109-2221-E-197-016-MY3 , 110-2221-E-197-008 ) from the Taiwan{\textquoteright}s Ministry of Science and Technology and 108-109 TEEP＠AsiaPlus Program from Taiwan's Ministry of Education . Authors are very thankful to Office of Research and Development, Chang Jung Christian University, for funding this study. Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2023",

month = jan,

doi = "10.1016/j.indcrop.2022.115944",

language = "English",

volume = "191",

journal = "Industrial Crops and Products",

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T1 - Interactive deciphering electron-shuttling characteristics of Coffea arabica leaves and potential bioenergy-steered anti-SARS-CoV-2 RdRp inhibitor via microbial fuel cells

AU - Tsai, Po Wei

AU - Tayo, Lemmuel L.

AU - Ting, Jasmine U.

AU - Hsieh, Cheng Yang

AU - Lee, Chia Jung

AU - Chen, Chih Ling

AU - Yang, Hsiao Chuan

AU - Tsai, Hsing Yu

AU - Hsueh, Chung Chuan

AU - Chen, Bor Yann

N1 - Funding Information: The authors sincerely appreciate financial supports ( MOST 109-2221-E-197-016-MY3 , 110-2221-E-197-008 ) from the Taiwan’s Ministry of Science and Technology and 108-109 TEEP＠AsiaPlus Program from Taiwan's Ministry of Education . Authors are very thankful to Office of Research and Development, Chang Jung Christian University, for funding this study. Publisher Copyright: © 2022 Elsevier B.V.

PY - 2023/1

Y1 - 2023/1

N2 - Due to the pandemics of COVID-19, herbal medicine has recently been explored for possible antiviral treatment and prevention via novel platform of microbial fuel cells. It was revealed that Coffea arabica leaves was very appropriate for anti-COVID-19 drug development. Antioxidant and anti-inflammatory tests exhibited the most promising activities for C. arabica ethanol extracts and drying approaches were implemented on the leaf samples prior to ethanol extraction. Ethanol extracts of C. arabica leaves were applied to bioenergy evaluation via DC-MFCs, clearly revealing that air-dried leaves (CA-A-EtOH) exhibited the highest bioenergy-stimulating capabilities (ca. 2.72 fold of power amplification to the blank). Furthermore, molecular docking analysis was implemented to decipher the potential of C. arabica leaves metabolites. Chlorogenic acid (−6.5 kcal/mol) owned the highest binding affinity with RdRp of SARS-CoV-2, showing a much lower average RMSF value than an apoprotein. This study suggested C. arabica leaves as an encouraging medicinal herb against SARS-CoV-2.

AB - Due to the pandemics of COVID-19, herbal medicine has recently been explored for possible antiviral treatment and prevention via novel platform of microbial fuel cells. It was revealed that Coffea arabica leaves was very appropriate for anti-COVID-19 drug development. Antioxidant and anti-inflammatory tests exhibited the most promising activities for C. arabica ethanol extracts and drying approaches were implemented on the leaf samples prior to ethanol extraction. Ethanol extracts of C. arabica leaves were applied to bioenergy evaluation via DC-MFCs, clearly revealing that air-dried leaves (CA-A-EtOH) exhibited the highest bioenergy-stimulating capabilities (ca. 2.72 fold of power amplification to the blank). Furthermore, molecular docking analysis was implemented to decipher the potential of C. arabica leaves metabolites. Chlorogenic acid (−6.5 kcal/mol) owned the highest binding affinity with RdRp of SARS-CoV-2, showing a much lower average RMSF value than an apoprotein. This study suggested C. arabica leaves as an encouraging medicinal herb against SARS-CoV-2.

KW - Biorefinery

KW - Chlorogenic acid

KW - Coffea arabica leaves

KW - COVID-19

KW - Microbial fuel cells

KW - RdRp

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Interactive deciphering electron-shuttling characteristics of Coffea arabica leaves and potential bioenergy-steered anti-SARS-CoV-2 RdRp inhibitor via microbial fuel cells

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