Interactions of antitumor drugs and DNA: crystallographic studies.

A. H. Wang, A. Rich

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

Several antitumor drugs complexed to DNA double helical fragments have been crystallized and their structures solved by single crystal X-ray diffraction analysis at high resolution. These studies show in great detail the manner in which the planar aromatic components of the drugs intercalate between base pairs from the minor groove side of B-DNA, as well as hydrogen bonding components which anchor the drug to DNA through its interaction with base pairs on either side of the intercalative site. Analysis at this level makes it possible to contemplate the rational design of antitumor drugs that might bind more strongly or interact more specifically with certain nucleic acid sequences.

原文英語
頁(從 - 到)49-51
頁數3
期刊Nucleic acids symposium series
發行號16
出版狀態已發佈 - 1985
對外發佈

ASJC Scopus subject areas

  • 一般醫學

指紋

深入研究「Interactions of antitumor drugs and DNA: crystallographic studies.」主題。共同形成了獨特的指紋。

引用此