Interaction between the left-handed Z-DNA and polyamine The crystal structure of the d(CG)3 and N-(2-aminoethyl)-1,4-diamino-butane complex

Hirofumi Ohishi; Shoko Kunisawa; Gijs van der Marel; Jacques H. van Boom; Alexander Rich; Andrew H.J. Wang; Ken ichi Tomita; Toshio Hakoshima

doi:10.1016/0014-5793(91)80694-X

Interaction between the left-handed Z-DNA and polyamine The crystal structure of the d(CG)₃ and N-(2-aminoethyl)-1,4-diamino-butane complex

Hirofumi Ohishi, Shoko Kunisawa, Gijs van der Marel, Jacques H. van Boom, Alexander Rich, Andrew H.J. Wang, Ken ichi Tomita, Toshio Hakoshima

研究成果: 雜誌貢獻 › 文章 › 同行評審

29 引文斯高帕斯（Scopus）

摘要

The DNA fragment d(CG)₃ was co-crystallized with N-(2-aminoethyl)-1,4-diaminobutane (PA(24)), a chemically synthesized polyamine. The complex crystal contained one polyamine, 3 magnesium cations and one sodium cation per duplex of d(CG)₃, and well diffracted the X-ray intensities up to 1.0 Å resolution. The d(CG)₃ took a left-handed Z-DNA conformation, and the PA(24) molecule electrostatically interacted with the phosphate groups of the d(CG)₃ duplex.

原文	英語
頁（從 - 到）	238-244
頁數	7
期刊	FEBS Letters
卷	284
發行號	2
DOIs	https://doi.org/10.1016/0014-5793(91)80694-X
出版狀態	已發佈 - 6月 24 1991
對外發佈	是

ASJC Scopus subject areas

生物物理學
結構生物學
生物化學
分子生物學
遺傳學
細胞生物學

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10.1016/0014-5793(91)80694-X

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引用此

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title = "Interaction between the left-handed Z-DNA and polyamine The crystal structure of the d(CG)3 and N-(2-aminoethyl)-1,4-diamino-butane complex",

abstract = "The DNA fragment d(CG)3 was co-crystallized with N-(2-aminoethyl)-1,4-diaminobutane (PA(24)), a chemically synthesized polyamine. The complex crystal contained one polyamine, 3 magnesium cations and one sodium cation per duplex of d(CG)3, and well diffracted the X-ray intensities up to 1.0 {\AA} resolution. The d(CG)3 took a left-handed Z-DNA conformation, and the PA(24) molecule electrostatically interacted with the phosphate groups of the d(CG)3 duplex.",

keywords = "Crystal structure, Molecular conformation, Molecular interaction, Polyamine, Z-DNA",

author = "Hirofumi Ohishi and Shoko Kunisawa and {van der Marel}, Gijs and {van Boom}, {Jacques H.} and Alexander Rich and Wang, {Andrew H.J.} and Tomita, {Ken ichi} and Toshio Hakoshima",

year = "1991",

month = jun,

day = "24",

doi = "10.1016/0014-5793(91)80694-X",

language = "English",

volume = "284",

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journal = "FEBS Letters",

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T1 - Interaction between the left-handed Z-DNA and polyamine The crystal structure of the d(CG)3 and N-(2-aminoethyl)-1,4-diamino-butane complex

AU - Ohishi, Hirofumi

AU - Kunisawa, Shoko

AU - van der Marel, Gijs

AU - van Boom, Jacques H.

AU - Rich, Alexander

AU - Wang, Andrew H.J.

AU - Tomita, Ken ichi

AU - Hakoshima, Toshio

PY - 1991/6/24

Y1 - 1991/6/24

N2 - The DNA fragment d(CG)3 was co-crystallized with N-(2-aminoethyl)-1,4-diaminobutane (PA(24)), a chemically synthesized polyamine. The complex crystal contained one polyamine, 3 magnesium cations and one sodium cation per duplex of d(CG)3, and well diffracted the X-ray intensities up to 1.0 Å resolution. The d(CG)3 took a left-handed Z-DNA conformation, and the PA(24) molecule electrostatically interacted with the phosphate groups of the d(CG)3 duplex.

AB - The DNA fragment d(CG)3 was co-crystallized with N-(2-aminoethyl)-1,4-diaminobutane (PA(24)), a chemically synthesized polyamine. The complex crystal contained one polyamine, 3 magnesium cations and one sodium cation per duplex of d(CG)3, and well diffracted the X-ray intensities up to 1.0 Å resolution. The d(CG)3 took a left-handed Z-DNA conformation, and the PA(24) molecule electrostatically interacted with the phosphate groups of the d(CG)3 duplex.

KW - Crystal structure

KW - Molecular conformation

KW - Molecular interaction

KW - Polyamine

KW - Z-DNA

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JO - FEBS Letters

JF - FEBS Letters

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Interaction between the left-handed Z-DNA and polyamine The crystal structure of the d(CG)3 and N-(2-aminoethyl)-1,4-diamino-butane complex

摘要

ASJC Scopus subject areas

存取文件

其它文件與鏈接

指紋

引用此

Interaction between the left-handed Z-DNA and polyamine The crystal structure of the d(CG)₃ and N-(2-aminoethyl)-1,4-diamino-butane complex