Integron-associated imipenem resistance in Acinetobacter baumannii isolated from a regional hospital in Taiwan

S. Y. Liu, J. Y. Lin, C. Chu, L. H. Su, T. Y. Lin, C. H. Chiu

研究成果: 雜誌貢獻文章同行評審

36 引文 斯高帕斯(Scopus)

摘要

We investigated the genetic properties of imipenem-resistant Acinetobacter baumannii collected from a regional hospital in Taiwan. Pulsed-field gel electrophoresis demonstrated that the isolates were genetically diverse. Polymerase chain reaction, DNA sequencing, and DNA-DNA hybridisation showed that the blaIMP-1 gene resided as a cassette in a plasmid-borne class 1 integron in two isolates. The majority of the resistant isolates were plasmid-less and carried no blaIMP, blaVIM or bla CFI genes, indicating that other uncharacterised metallo-β- lactamases or mechanisms other than enzyme production are involved in carbapenem resistance in this group of A. baumannii. We conclude that multidrug resistance of A. baumannii was a combined effect of lateral gene transfer and clonal spread of multiple resistant clones. Strict measures should be implemented to control the further spread of resistance.
原文英語
頁(從 - 到)81-84
頁數4
期刊International Journal of Antimicrobial Agents
27
發行號1
DOIs
出版狀態已發佈 - 1月 2006
對外發佈

ASJC Scopus subject areas

  • 應用微生物與生物技術
  • 微生物學
  • 寄生物學
  • 病毒學
  • 免疫學和過敏
  • 傳染性疾病

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