摘要
We investigated the genetic properties of imipenem-resistant Acinetobacter baumannii collected from a regional hospital in Taiwan. Pulsed-field gel electrophoresis demonstrated that the isolates were genetically diverse. Polymerase chain reaction, DNA sequencing, and DNA-DNA hybridisation showed that the blaIMP-1 gene resided as a cassette in a plasmid-borne class 1 integron in two isolates. The majority of the resistant isolates were plasmid-less and carried no blaIMP, blaVIM or bla CFI genes, indicating that other uncharacterised metallo-β- lactamases or mechanisms other than enzyme production are involved in carbapenem resistance in this group of A. baumannii. We conclude that multidrug resistance of A. baumannii was a combined effect of lateral gene transfer and clonal spread of multiple resistant clones. Strict measures should be implemented to control the further spread of resistance.
原文 | 英語 |
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頁(從 - 到) | 81-84 |
頁數 | 4 |
期刊 | International Journal of Antimicrobial Agents |
卷 | 27 |
發行號 | 1 |
DOIs | |
出版狀態 | 已發佈 - 1月 2006 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 應用微生物與生物技術
- 微生物學
- 寄生物學
- 病毒學
- 免疫學和過敏
- 傳染性疾病