Treatment of quiescent Balb c 3T3 cells with insulin-like growth factor I (IGF I) resulted in the stimulation of proto-oncogene c-jun transcription. Cells exposed to cycloheximide and IGF I together showed super-induction of c-jun transcripts. Nuclear run-off assay revealed that IGF I up-regulated c-jun only while cycloheximide was present. The stability of c-jun mRNA was markedly increased in the cells treated with IGF I. These results suggest that IGF I controls the expression of c-jun by increasing the transcriptional activity and stabilizing the existing transcripts.
|頁（從 - 到）||524-531|
|期刊||Biochemical and Biophysical Research Communications|
|出版狀態||已發佈 - 3月 16 1992|
ASJC Scopus subject areas