摘要
Treatment of quiescent Balb c 3T3 cells with insulin-like growth factor I (IGF I) resulted in the stimulation of proto-oncogene c-jun transcription. Cells exposed to cycloheximide and IGF I together showed super-induction of c-jun transcripts. Nuclear run-off assay revealed that IGF I up-regulated c-jun only while cycloheximide was present. The stability of c-jun mRNA was markedly increased in the cells treated with IGF I. These results suggest that IGF I controls the expression of c-jun by increasing the transcriptional activity and stabilizing the existing transcripts.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 524-531 |
| 頁數 | 8 |
| 期刊 | Biochemical and Biophysical Research Communications |
| 卷 | 183 |
| 發行號 | 2 |
| DOIs | |
| 出版狀態 | 已發佈 - 3月 16 1992 |
| 對外發佈 | 是 |
ASJC Scopus subject areas
- 生物物理學
- 生物化學
- 分子生物學
- 細胞生物學