TY - JOUR
T1 - Instability of spontaneous breathing patterns in patients with persistent vegetative state
AU - Bien, Mauo Ying
AU - Yien, Huey Wen
AU - Hseu, Shu Shya
AU - Wang, Jia Horng
AU - Kou, Yu Ru
PY - 2005/2
Y1 - 2005/2
N2 - We investigated the breathing patterns of 27 patients in a persistent vegetative state (PVS) and 15 normal control volunteers. During the baseline period breathing air, 15 patients (the PVS-IB) exhibited irregular breathing (IB), whereas the other 12 (the PVS-OB) displayed oscillatory breathing (OB). Both groups maintained an average value for tidal volume (VT), total breath duration (TTOT), minute ventilation (V̇E), oxygen saturation (SpO2) similar to the control, but the PVS-OB displayed significantly lower end-tidal CO2 tension (P ETCO2) than the control. The VT, T TOT, V̇E and PETCO2 of the PVS-OB showed cyclic changes. The coefficients of variation of VT, TTOT and V̇I were: PVS-OB > PVS-IB > control. Inhalation of 100% O2 significantly reduced the respiratory variability and prevented OB of the PVS-OB. We concluded that PVS patients display respiratory instability and that brain damage, hypocapnia, and/or increased loop gain of arterial chemoreceptors may contribute to the pathogenesis of OB, whereas brain damage presumably may be the cause of IB.
AB - We investigated the breathing patterns of 27 patients in a persistent vegetative state (PVS) and 15 normal control volunteers. During the baseline period breathing air, 15 patients (the PVS-IB) exhibited irregular breathing (IB), whereas the other 12 (the PVS-OB) displayed oscillatory breathing (OB). Both groups maintained an average value for tidal volume (VT), total breath duration (TTOT), minute ventilation (V̇E), oxygen saturation (SpO2) similar to the control, but the PVS-OB displayed significantly lower end-tidal CO2 tension (P ETCO2) than the control. The VT, T TOT, V̇E and PETCO2 of the PVS-OB showed cyclic changes. The coefficients of variation of VT, TTOT and V̇I were: PVS-OB > PVS-IB > control. Inhalation of 100% O2 significantly reduced the respiratory variability and prevented OB of the PVS-OB. We concluded that PVS patients display respiratory instability and that brain damage, hypocapnia, and/or increased loop gain of arterial chemoreceptors may contribute to the pathogenesis of OB, whereas brain damage presumably may be the cause of IB.
KW - Brain damage
KW - Control of breathing
KW - Irregular breathing
KW - Oscillatory breathing
KW - Peripheral chemoreceptors
KW - Respiratory plasticity
UR - http://www.scopus.com/inward/record.url?scp=13444261151&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13444261151&partnerID=8YFLogxK
U2 - 10.1016/j.resp.2004.09.007
DO - 10.1016/j.resp.2004.09.007
M3 - Article
C2 - 15705532
AN - SCOPUS:13444261151
SN - 1569-9048
VL - 145
SP - 163
EP - 175
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
IS - 2-3
ER -