摘要
The inside cover picture shows a SAR study of synthetic N-hydroxyacrylamides, described by J.-P. Liou et al. on p. 1248 ff., that identified 3-[1- (4-methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-5-yl]-N-hydroxyacrylamide as a potent HDAC inhibitor. This compound not only suppresses the production of lipopolysaccharide-induced cytokines but also markedly reduces carrageenan-induced inflammation in rat. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
原文 | 英語 |
---|---|
頁(從 - 到) | 1150 |
頁數 | 1 |
期刊 | ChemBioChem |
卷 | 14 |
發行號 | 10 |
DOIs | |
出版狀態 | 已發佈 - 7月 2013 |
Keywords
- Anti-inflammatory agents
- Gene expression
- Histone deacetylase
- Indolines
- Inhibitors
ASJC Scopus subject areas
- 生物化學
- 有機化學
- 分子醫學
- 分子生物學