TY - JOUR
T1 - Inhibitory effects of polyphenolic catechins from Chinese green tea on HIV reverse transcriptase activity
AU - Chang, C. W.
AU - Hsu, F. L.
AU - Lin, J. Y.
PY - 1994/6
Y1 - 1994/6
N2 - Three polyphenolic catechins, epigallocatechin (1), epicatechin-3-O-gallate (2) and epigallocatechin-3-O-gallate (3), were isolated from Chinese green tea, Ti-Kaun-Yin (Camellia sinensis) and demonstrated as a new class of human immunodeficiency virus-reverse transcriptase (HIV-RT) inhibitor. The concentrations required for 50% inhibition for the compounds (1), (2) and (3) were 7.80, 0.32 and 0.68 μM, respectively. The polyphenolic catechins with a galloyl group at the 3 position were potent inhibitors of HIV-RT. Kinetic analysis indicated that the polyphenolic catechins were competitive inhibitors with respect to the template-primer (rA)n(dT)12-18 and noncompetitive inhibitors to dTTP.
AB - Three polyphenolic catechins, epigallocatechin (1), epicatechin-3-O-gallate (2) and epigallocatechin-3-O-gallate (3), were isolated from Chinese green tea, Ti-Kaun-Yin (Camellia sinensis) and demonstrated as a new class of human immunodeficiency virus-reverse transcriptase (HIV-RT) inhibitor. The concentrations required for 50% inhibition for the compounds (1), (2) and (3) were 7.80, 0.32 and 0.68 μM, respectively. The polyphenolic catechins with a galloyl group at the 3 position were potent inhibitors of HIV-RT. Kinetic analysis indicated that the polyphenolic catechins were competitive inhibitors with respect to the template-primer (rA)n(dT)12-18 and noncompetitive inhibitors to dTTP.
KW - HIV reverse transcriptase activity
KW - Polyphenolic catechins
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U2 - 10.1007/BF02253344
DO - 10.1007/BF02253344
M3 - Article
AN - SCOPUS:0000425753
SN - 1021-7770
VL - 1
SP - 163
EP - 166
JO - Journal of Biomedical Science
JF - Journal of Biomedical Science
IS - 3
ER -
