摘要
A new chemical entity, namely kaempferol 3-O-α-L-[2-(Z)-p-coumaroyl- 4-(E)-p-coumaroyl]rhamnopyranoside(1), and the known kaempferol 3-O-α-L-[2,4-di-(E)-p-coumaroyl]rhamnopyranoside (2) have been isolated from the methanolic extract of leaves of Cinnamomum kotoense. Structural elucidation of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. The effects of compounds 1 and 2 on phytohemagglutinin (PHA) stimulated cell proliferation were studied towards human peripheral blood mononuclear cells (PBMC). The results indicated that compounds 1 and 2 suppressed PBMC proliferation induced by PHA with an IC50 value of 5.0 ± 1.3 and 6.0 ± 1.5 μM, respectively. Interleukin-2 production in activated PBMC inhibited by compounds 1 and 2 were in a concentration-dependent manner. Therefore, we suggested that compounds 1 and 2 in C. kotoense were likely the growth modulators for PBMC. copy; Georg Thieme Verlag KG Stuttgart.
原文 | 英語 |
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頁(從 - 到) | 412-415 |
頁數 | 4 |
期刊 | Planta Medica |
卷 | 71 |
發行號 | 5 |
DOIs | |
出版狀態 | 已發佈 - 5月 2005 |
ASJC Scopus subject areas
- 植物科學
- 藥物發現
- 有機化學
- 藥理