Inhibitory effect of some selected nutraceutic herbs on LDL glycation induced by glucose and glyoxal

Chiu Lan Hsieh, Yuh Charn Lin, Wang Sheng Ko, Chiung Hui Peng, Chien Ning Huang, Robert Y. Peng

研究成果: 雜誌貢獻文章同行評審

72 引文 斯高帕斯(Scopus)


Anti-LDL glycative agents were investigated using aqueous extracts of Psidium guajava L. (PE), Toona sinensis Roem. (TE), Momordica charantia L. (ME) and Graptopetalum paragugayene E. Walther (GE). Concentrations of extracts 0.01-0.625 mg/mL, low density lipoprotein (LDL; 100 μg protein/mL) and inducers glucose (400 mM) and glyoxal (2.5 mM) were incubated at 37°C. Evaluation parameters involved the thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD), relative electrophoretic mobility (REM), 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging capability and total polyphenolic content. Results for anti-TBARS efficiency (in%) were PE (75.77), TE (75.10), ME (68.81) and GE (19.81) at 0.5 mg/mL, respectively, when induced by glucose; 36.68, 35.60, 32.62 and inactive, respectively, by glyoxal. The lag times for CD formation (in min) were: 289 and 125 by PE and TE, respectively, comparing to the control (45). REM was 1.6 with respect to PE (0.1 mg/mL) compared to the control (4.2). PE at 0.01 mg/mL effectively inhibited with 63.45% efficiency on AGEs induced by glucose. We conclude that PE virtually is a potent antiglycative agent, which can be of great value in the preventive glycation-associated cardiovascular and neurodegenerative diseases.
頁(從 - 到)357-363
期刊Journal of Ethnopharmacology
出版狀態已發佈 - 12月 1 2005

ASJC Scopus subject areas

  • 藥理
  • 藥物發現


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