Inhibitory effect of resveratrol on angiotensin II-induced cardiomyocyte hypertrophy

Tzu Hurng Cheng, Ju Chi Liu, Heng Lin, Neng Lang Shih, Yen Ling Chen, Meng Ting Huang, Paul Chan, Ching Feng Cheng, Jin Jer Chen

研究成果: 雜誌貢獻文章同行評審

44 引文 斯高帕斯(Scopus)

摘要

Resveratrol is proposed to account in part for the protective effect of red wine on the cardiovascular system. Angiotensin II (Ang II) is a potent hypertrophic stimulus in cardiomyocytes. In this study, we determined the effect of resveratrol on Ang II-induced cardiomyocyte hypertrophy. Cultured neonatal rat cardiomyocytes were stimulated with Ang II, and [ 3H]leucine incorporation and β-myosin heavy chain (β-MyHC) promoter activity were examined. Intracellular reactive oxygen species (ROS) were measured by a redox-sensitive fluorescent dye, 2′ 7′-dichlorofluorescin diacetate, and the extracellular signal-regulated kinase (ERK) phosphorylation was examined by Western blotting. Resveratrol inhibited Ang II-increased intracellular ROS levels. Furthermore, resveratrol, as well as the antioxidant N-acetyl-cysteine, decreased Ang II- or H 2O 2-increased protein synthesis, β-MyHC promoter activity, and ERK phosphorylation. In summary, we demonstrate for the first time that resveratrol inhibits Ang II-induced cardiomyocyte hypertrophy via attenuation of ROS generation.
原文英語
頁(從 - 到)239-244
頁數6
期刊Naunyn-Schmiedeberg's Archives of Pharmacology
369
發行號2
DOIs
出版狀態已發佈 - 2月 2004

ASJC Scopus subject areas

  • 藥理

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