摘要
Eighteen anthraquinones and related compounds were tested for their inhibitory effects on xanthine oxidase. The enzyme, xanthine oxidase catalyses the oxidation of hypoxanthine to xanthine and of xanthine to uric acid, which has a λmax of 295 nm, forming the basis for a spectrophotometric assay of the activity of xanthine oxidase. The results showed that anthrarobin and purpurin showed moderate effects on xanthine oxidase inhibition (IC50 = 68.35 and 105.13 μM; Ki = 122.38 mid 130.49 μM respectively), and both of them induced mixed type (competitive-non-competitive) inhibition with respect to the substrate xanthine.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 3293-3297 |
| 頁數 | 5 |
| 期刊 | Anticancer Research |
| 卷 | 17 |
| 發行號 | 5 A |
| 出版狀態 | 已發佈 - 9月 1997 |
ASJC Scopus subject areas
- 腫瘤科
- 癌症研究
