Influences of cardiac mechano-electrical feedback on action potential duration

J. C. Hsieh; Shih Ann Chen; Cheng Jeng Tai; John K J Li

Influences of cardiac mechano-electrical feedback on action potential duration

J. C. Hsieh, Shih Ann Chen, Cheng Jeng Tai, John K J Li

研究成果: 書貢獻/報告類型 › 會議貢獻

摘要

A mathematical model of ventricular tissue, incorporated into stretch-activated channels (SACs) and volume-activated chloride currents (Icl,swell), was developed to investigate the interactions between cellular geometry and gap junctions in modulating action potential duration (APD). Results showed that (1) Shortening of APD was observed by activation of SACs using sustained axis-stretch in cellular uncoupling; however, lengthening of APD was observed in cellular coupling. (2) Shortening of APD was observed by activation of Icl,swell using radial swelling in both coupling and uncoupling. Thus, the alteration of APD by mechano-electrical feedback (MEF) in various gap junctions can be arrhythmogenic.

原文	英語
主出版物標題	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
發行者	IEEE
頁面	142
頁數	1
卷	1
ISBN（列印）	0780356756
出版狀態	已發佈 - 1999
對外發佈	是
事件	Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA 持續時間: 10月 13 1999 → 10月 16 1999

其他

其他	Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
城市	Atlanta, GA, USA
期間	10/13/99 → 10/16/99

ASJC Scopus subject areas

生物工程

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Hsieh, JC, Chen, SA, Tai, CJ & Li, JKJ 1999, Influences of cardiac mechano-electrical feedback on action potential duration. 於 Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 卷 1, IEEE, 頁 142, Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS), Atlanta, GA, USA, 10/13/99.

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abstract = "A mathematical model of ventricular tissue, incorporated into stretch-activated channels (SACs) and volume-activated chloride currents (Icl,swell), was developed to investigate the interactions between cellular geometry and gap junctions in modulating action potential duration (APD). Results showed that (1) Shortening of APD was observed by activation of SACs using sustained axis-stretch in cellular uncoupling; however, lengthening of APD was observed in cellular coupling. (2) Shortening of APD was observed by activation of Icl,swell using radial swelling in both coupling and uncoupling. Thus, the alteration of APD by mechano-electrical feedback (MEF) in various gap junctions can be arrhythmogenic.",

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AB - A mathematical model of ventricular tissue, incorporated into stretch-activated channels (SACs) and volume-activated chloride currents (Icl,swell), was developed to investigate the interactions between cellular geometry and gap junctions in modulating action potential duration (APD). Results showed that (1) Shortening of APD was observed by activation of SACs using sustained axis-stretch in cellular uncoupling; however, lengthening of APD was observed in cellular coupling. (2) Shortening of APD was observed by activation of Icl,swell using radial swelling in both coupling and uncoupling. Thus, the alteration of APD by mechano-electrical feedback (MEF) in various gap junctions can be arrhythmogenic.

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Influences of cardiac mechano-electrical feedback on action potential duration

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