Influence of Helicobacter pylori on gastric secretion and gastrin release in normal Chinese subjects

Guan Ying Tseng, Hwai Jeng Lin, Hsiao Yi Lin, Chin Lin Perng, Fa Yauh Lee, Wen Ching Lo, Shyh Haw Tsay, Anna Fen Yau Li, Full Young Chang, Shou Dong Lee

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)


Background. Controversy exists concerning the influence of Helicobacter pylori on gastric secretion. Hyper-, normo- and hyposecretion of gastric acid in normal subjects with H pylori infection have been reported, although there is no such report for Chinese subjects. The goal of this study was to identify the effect of H pylori on gastric secretion in normal Chinese subjects. Methods. Twenty normal subjects with a normal upper gastrointestinal tract by endoscopy were recruited. H pylori status was assayed by a rapid urease test. Gastric secretion and gastrin release were also measured. Results. Among the subjects studied, nine were infected with H pylori. All enrolled subjects were males. Age and body weight were similar between both groups. No significant difference was found in basal acid output, maximal acid output, basal pepsin output or maximal pepsin output between the H pylori-positive group (median, 1.1 mmol/hour, 95% confidence interval 0.2-3.6 mmol/hour; 8.0, 3.0-18.3 mmol/hour; 0, -1.3-11.2 mmol/hour; and 4.1, -4.2-59.3 mmol/hour, respectively) and the H pylori-negative group (2.5, -1.3-11.3 mmol/hour; 12.2, 8.7-26.9 mmol/hour; 4.3, 1.8-13.5 mmol/hour; and 14.8, -5.7-73.0 mmol/hour, respectively). Serum basal gastrin and pepsinogen I concentration were 63.5, 50.0-78.6 pg/ml and 75.1, 50.6-89.8 ng/ml in the H pylori-positive group, and 65.9,50.2-79.8 pg/ml and 79.1, 59.5-120.1 ng/ml in the H pylori-negative group (p > 0.05). Conclusions. H pylori plays no role in the gastric secretion and gastrin release in normal Chinese subjects.

頁(從 - 到)217-222
期刊Chinese Medical Journal (Taipei)
出版狀態已發佈 - 4月 1999

ASJC Scopus subject areas

  • 一般醫學


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