TY - JOUR
T1 - Infectivity and pathogenicity of 14-month-cultured embryonated eggs of Toxocara canis in mice
AU - Fan, Chia Kwung
AU - Lin, Yun Ho
AU - Du, Wen Yuan
AU - Su, Kua Eyre
N1 - Funding Information:
The authors are grateful to Taipei Medical University for its support of this research (grants TMU-86-Y05-B101 and TMU-88-Y05-A106). We also thank Mr. D. J. Kao and Mr. C. W. Liao for expert technical assistance, and the Taipei Municipal Institute for Animal Health is acknowledged for providing experimental stray dogs from which adult T. canis worms were collected.
PY - 2003/4/18
Y1 - 2003/4/18
N2 - Infectivity and pathogenicity to mice of embryonated eggs of Toxocara canis, that had been maintained in 2% formalin for 14 months at 4°C, were evaluated by immunological and pathological assessment at 1, 4, 8, 12, 16, 20, 24, 28, 42 and 67 weeks post-infection (WPI). On each date, three infected mice and two age-matched uninfected mice were sacrificed for serum collection and histological processing of the liver, lungs, musculature, and brain. Infectivity assessment by enzyme-linked immunosorbent assay (ELISA) revealed that the overall immunological pattern of infected mice tended to be towards the Th2 type response. Serum IgG1 antibody titers in infected mice were significantly higher than that of the uninfected control mice throughout the trial (P
AB - Infectivity and pathogenicity to mice of embryonated eggs of Toxocara canis, that had been maintained in 2% formalin for 14 months at 4°C, were evaluated by immunological and pathological assessment at 1, 4, 8, 12, 16, 20, 24, 28, 42 and 67 weeks post-infection (WPI). On each date, three infected mice and two age-matched uninfected mice were sacrificed for serum collection and histological processing of the liver, lungs, musculature, and brain. Infectivity assessment by enzyme-linked immunosorbent assay (ELISA) revealed that the overall immunological pattern of infected mice tended to be towards the Th2 type response. Serum IgG1 antibody titers in infected mice were significantly higher than that of the uninfected control mice throughout the trial (P
KW - Embryonated eggs
KW - Infectivity
KW - Mouse
KW - Pathogenicity
KW - Toxocara canis
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U2 - 10.1016/S0304-4017(03)00046-3
DO - 10.1016/S0304-4017(03)00046-3
M3 - Article
C2 - 12695039
AN - SCOPUS:0344406810
SN - 0304-4017
VL - 113
SP - 145
EP - 155
JO - Veterinary Parasitology: Regional Studies and Reports
JF - Veterinary Parasitology: Regional Studies and Reports
IS - 2
ER -