TY - JOUR
T1 - Induction of c-Fos immunoreactivity in the rat forebrain by conditioned and unconditioned aversive stimuli
AU - Pezzone, Michael A.
AU - Lee, Wen Sen
AU - Hoffman, Gloria E.
AU - Rabin, Bruce S.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1992/11/27
Y1 - 1992/11/27
N2 - The protein product of the c-fos proto-oncogene was immunocytochemically localized in forebrain regions of adult male Lewis rats subjected to a physically aversive footshock stimulus or a Pavlovian-conditioned, non-aversive, auditory stimulus. Animals receiving the conditioned stimulus were first conditioned by repeatedly pairing electric footshock, the unconditioned stimulus (US), with an auditory cue, the conditioned stimulus (CS). These animals were later tested with the CS in the absence of the US, a procedure which, like footshock itself, suppresses immune function. In animals exposed to the conditioned or unconditioned stressor, c-Fos was strongly expressed in cells of the paraventricular nuclei (PVN) of the hypothalamus, some of which contain corticotropin-releasing hormone (CRH), and other forebrain areas directly associated with autonomic function, the ventral lateal septal nuclei (LSV), the medial amygdaloid nuclei (AME), the sensorimotor cortex, the basal ganglia and thalamic nuclei. Control animals exhibited very little or no c-Fos in the above areas. The identified forebrain nuclei can now be targeted for further study aimed at elucidating their role in stress-induced immune alteration.
AB - The protein product of the c-fos proto-oncogene was immunocytochemically localized in forebrain regions of adult male Lewis rats subjected to a physically aversive footshock stimulus or a Pavlovian-conditioned, non-aversive, auditory stimulus. Animals receiving the conditioned stimulus were first conditioned by repeatedly pairing electric footshock, the unconditioned stimulus (US), with an auditory cue, the conditioned stimulus (CS). These animals were later tested with the CS in the absence of the US, a procedure which, like footshock itself, suppresses immune function. In animals exposed to the conditioned or unconditioned stressor, c-Fos was strongly expressed in cells of the paraventricular nuclei (PVN) of the hypothalamus, some of which contain corticotropin-releasing hormone (CRH), and other forebrain areas directly associated with autonomic function, the ventral lateal septal nuclei (LSV), the medial amygdaloid nuclei (AME), the sensorimotor cortex, the basal ganglia and thalamic nuclei. Control animals exhibited very little or no c-Fos in the above areas. The identified forebrain nuclei can now be targeted for further study aimed at elucidating their role in stress-induced immune alteration.
KW - Corticotropin-releasing hormone
KW - Dorsomedial nucleus
KW - Footshock
KW - Lateral septal nucleus
KW - Medial amygdaloid nucleus
KW - Neuroimmunomodulation
KW - Paraventricular nucleus
KW - c-Fos
UR - http://www.scopus.com/inward/record.url?scp=0026497519&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026497519&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(92)91503-7
DO - 10.1016/0006-8993(92)91503-7
M3 - Article
C2 - 1477734
AN - SCOPUS:0026497519
SN - 0006-8993
VL - 597
SP - 41
EP - 50
JO - Brain Research
JF - Brain Research
IS - 1
ER -