Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21

Yu Fang Kuang; Yue-Hwa Chen

doi:10.1016/j.fct.2004.06.009

Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21

Yu Fang Kuang, Yue-Hwa Chen

研究成果: 雜誌貢獻 › 文章 › 同行評審

68 引文斯高帕斯（Scopus）

摘要

This study was aimed at examining the effects of glucosinolate derivatives including phenylethyl isothiocyanate (PEITC), benzyl isothiocyanate (BITC), and indole-3-carbinol (I3C), on the induction of apoptosis in human non-small cell lung carcinoma A549 cells. The results indicated that all tested compounds inhibited the growth of A549 cells in a concentration-dependent manner. Flow cytometric analyses and annexin V staining showed that induction of apoptosis occurred at low concentrations of PEITC and BITC (â

原文	英語
頁（從 - 到）	1711-1718
頁數	8
期刊	Food and Chemical Toxicology
卷	42
發行號	10
DOIs	https://doi.org/10.1016/j.fct.2004.06.009
出版狀態	已發佈 - 10月 2004

ASJC Scopus subject areas

食品科學
毒理學

UN SDG

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10.1016/j.fct.2004.06.009

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title = "Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21",

abstract = "This study was aimed at examining the effects of glucosinolate derivatives including phenylethyl isothiocyanate (PEITC), benzyl isothiocyanate (BITC), and indole-3-carbinol (I3C), on the induction of apoptosis in human non-small cell lung carcinoma A549 cells. The results indicated that all tested compounds inhibited the growth of A549 cells in a concentration-dependent manner. Flow cytometric analyses and annexin V staining showed that induction of apoptosis occurred at low concentrations of PEITC and BITC ({\^a}",

keywords = "Apoptosis, Indole-3-carbinol, Isothiocyanate, Lung adenocarcinoma A549 cells, P21, P53",

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N2 - This study was aimed at examining the effects of glucosinolate derivatives including phenylethyl isothiocyanate (PEITC), benzyl isothiocyanate (BITC), and indole-3-carbinol (I3C), on the induction of apoptosis in human non-small cell lung carcinoma A549 cells. The results indicated that all tested compounds inhibited the growth of A549 cells in a concentration-dependent manner. Flow cytometric analyses and annexin V staining showed that induction of apoptosis occurred at low concentrations of PEITC and BITC (â

AB - This study was aimed at examining the effects of glucosinolate derivatives including phenylethyl isothiocyanate (PEITC), benzyl isothiocyanate (BITC), and indole-3-carbinol (I3C), on the induction of apoptosis in human non-small cell lung carcinoma A549 cells. The results indicated that all tested compounds inhibited the growth of A549 cells in a concentration-dependent manner. Flow cytometric analyses and annexin V staining showed that induction of apoptosis occurred at low concentrations of PEITC and BITC (â

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KW - Indole-3-carbinol

KW - Isothiocyanate

KW - Lung adenocarcinoma A549 cells

KW - P21

KW - P53

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Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21

摘要

ASJC Scopus subject areas

UN SDG

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