Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization

Yuh Cherng Guo; Che Mai Chang; Wen Li Hsu; Siou Jin Chiu; Yao Ting Tsai; Yii Her Chou; Ming Feng Hou; Jaw Yan Wang; Mei Hsien Lee; Ke Li Tsai; Wei Chiao Chang

doi:10.3390/molecules18066584

Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization

Yuh Cherng Guo, Che Mai Chang, Wen Li Hsu, Siou Jin Chiu, Yao Ting Tsai, Yii Her Chou, Ming Feng Hou, Jaw Yan Wang, Mei Hsien Lee, Ke Li Tsai, Wei Chiao Chang

研究成果: 雜誌貢獻 › 文章 › 同行評審

52 引文斯高帕斯（Scopus）

摘要

Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca²⁺ influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.

原文	英語
頁（從 - 到）	6584-6596
頁數	13
期刊	Molecules
卷	18
發行號	6
DOIs	https://doi.org/10.3390/molecules18066584
出版狀態	已發佈 - 6月 2013

ASJC Scopus subject areas

分析化學
化學（雜項）
分子醫學
藥學科學
藥物發現
物理與理論化學
有機化學

UN SDG

此研究成果有助於以下永續發展目標

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10.3390/molecules18066584

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引用此

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title = "Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization",

abstract = "Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca2+ influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.",

keywords = "COX-2, Cell migration, EGF, Indomethacin",

author = "Guo, {Yuh Cherng} and Chang, {Che Mai} and Hsu, {Wen Li} and Chiu, {Siou Jin} and Tsai, {Yao Ting} and Chou, {Yii Her} and Hou, {Ming Feng} and Wang, {Jaw Yan} and Lee, {Mei Hsien} and Tsai, {Ke Li} and Chang, {Wei Chiao}",

year = "2013",

month = jun,

doi = "10.3390/molecules18066584",

language = "English",

volume = "18",

pages = "6584--6596",

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T1 - Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization

AU - Guo, Yuh Cherng

AU - Chang, Che Mai

AU - Hsu, Wen Li

AU - Chiu, Siou Jin

AU - Tsai, Yao Ting

AU - Chou, Yii Her

AU - Hou, Ming Feng

AU - Wang, Jaw Yan

AU - Lee, Mei Hsien

AU - Tsai, Ke Li

AU - Chang, Wei Chiao

PY - 2013/6

Y1 - 2013/6

N2 - Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca2+ influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.

AB - Non-steroidal anti-inflammatory drugs (NSAIDs) were shown to reduce the risk of colorectal cancer recurrence and are widely used to modulate inflammatory responses. Indomethacin is an NSAID. Herein, we reported that indomethacin can suppress cancer cell migration through its influence on the focal complexes formation. Furthermore, endothelial growth factor (EGF)-mediated Ca2+ influx was attenuated by indomethacin in a dose dependent manner. Our results identified a new mechanism of action for indomethacin: inhibition of calcium influx that is a key determinant of cancer cell migration.

KW - COX-2

KW - Cell migration

KW - EGF

KW - Indomethacin

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DO - 10.3390/molecules18066584

M3 - Article

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EP - 6596

JO - Molecules

JF - Molecules

IS - 6

ER -

Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization

摘要

ASJC Scopus subject areas

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